Dihydroceramide desaturase promotes the formation of intraluminal vesicles and inhibits autophagy to increase exosome production
Journal
iScience
Journal Volume
24
Journal Issue
12
Pages
103437
Date Issued
2021
Author(s)
Wu C.-Y.
Jhang J.-G.
Lin W.-S.
Chuang P.-H.
Lin C.-W.
Chiang A.-S.
Ho H.-C.
Huang S.-Y.
Abstract
. Together, DEGS1/Ifc controls the dihydroceramide-to-ceramide ratio and enhances exosome secretion by promoting ILV formation and preventing the autophagic degradation of MVEs. These findings provide a potential cause for the neuropathy associated with DEGS1-deficient mutations.
SDGs
Publisher
Elsevier Inc.
Type
journal article