https://scholars.lib.ntu.edu.tw/handle/123456789/594620
標題: | Differential whole-genome doubling and homologous recombination deficiencies across breast cancer subtypes from the Taiwanese population | 作者: | Wu, Chia-Hsin Hsieh, Chia-Shan Chang, Yo-Cheng Huang, Chi-Cheng Yeh, Hsien-Tan Hou, Ming-Feng Chung, Yuan-Chiang Tu, Shih-Hsin KING-JEN CHANG Chattopadhyay A. Liang-Chuan Lai TZU-PIN LU Li, Yung-Hua MONG-HSUN TSAI ERIC YAO-YU CHUANG |
公開日期: | 2021 | 出版社: | Nature Research | 卷: | 4 | 期: | 1 | 起(迄)頁: | 1052 | 來源出版物: | Communications Biology | 摘要: | Whole-genome doubling (WGD) is an early macro-evolutionary event in tumorigenesis, involving the doubling of an entire chromosome complement. However, its impact on breast cancer subtypes remains unclear. Here, we performed a comprehensive and quantitative analysis of WGD and its influence on breast cancer subtypes in patients from Taiwan and consequently highlight the genomic association between WGD and homologous recombination deficiency (HRD). A higher manifestation of WGD was reported in triple-negative breast cancer, conferring high chromosomal instability (CIN), while HER2 + tumors exhibited early WGD events, with widely varied CIN levels, compared to luminal-type tumors. An association of higher activity of de novo indel signature 2 with WGD and HRD in Taiwanese breast cancer patients was reported. A control test between WGD and pseudo non-WGD samples was further employed to support this finding. The study provides a better comprehension of tumorigenesis in breast cancer subtypes, thus assisting in personalized treatment. © 2021, The Author(s). |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114685446&doi=10.1038%2fs42003-021-02597-x&partnerID=40&md5=0e851f0ba115246a64f726a666b98adb https://scholars.lib.ntu.edu.tw/handle/123456789/594620 |
ISSN: | 23993642 | DOI: | 10.1038/s42003-021-02597-x | SDG/關鍵字: | adult; aged; breast tumor; classification; female; genetics; homologous recombination; human; human genome; middle aged; mutation; Taiwan; very elderly; Adult; Aged; Aged, 80 and over; Breast Neoplasms; Female; Genome, Human; Homologous Recombination; Humans; Middle Aged; Mutation; Taiwan |
顯示於: | 生理學科所 |
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