https://scholars.lib.ntu.edu.tw/handle/123456789/595342
Title: | Fourteen-day sequential therapy is superior to 7-day triple therapy as first-line regimen for Helicobacter pylori infected children | Authors: | Su, Da Jyun Chang, Mei Hwei JYH-CHIN YANG YEN-HSUAN NI HONG-YUAN HSU JIA-FENG WU |
Keywords: | Children | Eradication | Helicobacter pylori | Resistance | Sequential therapy | Issue Date: | 1-Jan-2022 | Publisher: | ELSEVIER TAIWAN | Journal Volume: | 121 | Journal Issue: | 1 | Start page/Pages: | 202 | Source: | Journal of the Formosan Medical Association | Abstract: | Background/purpose: Helicobacter pylori infection is one of the most common causes of peptic ulcer disease among children. This study is aimed to investigate the eradication rate of 14-day sequential therapy and the antibiotic resistance of H. pylori in children. Methods: Eighty-seven treatment-naïve children (55 males; median age, 13.5 years) with H. pylori infection from January 2009 to August 2019 were recruited in this study. The status of H. pylori infection was confirmed by culture or histology with the aid of urea rapid test or C-13 urea breathe test. Patients treated with either triple therapy for 7 days or 14 days, or sequential therapy for 14 days was analyzed retrospectively. Results: Thirty-eight (43.7%) patients received 14-day sequential therapy, 24 (27.6%) patients received 14-day triple therapy and the remaining 25 (28.7%) patients received 7-day triple therapy. The eradication rate of 14-day sequential therapy was significantly superior to 7-day triple therapy (97.4% vs. 80%, p = 0.032), and tended to be better than 14-day triple therapy (83%, p = 0.07). Of the 54 patients with available antibiotic resistance data, the resistant rate of clarithromycin, metronidazole, levofloxacin, and amoxicillin were 22.2%, 16.7%, 9.1% and 2.2%, respectively. Clarithromycin resistance demonstrated an inverse association with eradication success (Odds ratio = 0.017, p < 0.001). Conclusion: In treatment-naïve children with H. pylori infection, 14-day sequential therapy is superior to triple therapy, and achieve a high eradication rate (above 90%) in an area of high clarithromycin resistance. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/595342 | ISSN: | 09296646 | DOI: | 10.1016/j.jfma.2021.03.001 | SDG/Keyword: | amoxicillin; clarithromycin; dexlansoprazole; esomeprazole; lansoprazole; levofloxacin; metronidazole; proton pump inhibitor; rabeprazole; urea; urea c 13; adolescent; amoxicillin resistance; antibiotic resistance; antibiotic therapy; Article; bacterial c |
Appears in Collections: | 醫學教育暨生醫倫理學科所 |
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