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  1. NTU Scholars
  2. 醫學院
  3. 醫學教育暨生醫倫理學科所
Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/595739
Title: Kinetics of hepatitis B surface antigen in pregnant women with and without tenofovir disoproxil fumarate
Authors: Chang, Huai-Lung
Wen, Wan-Hsin
CHIEN-NAN LEE 
Chiu, Yu-En
CHUN-JEN LIU 
Chang, Mei-Hwei
Lin, Lung-Huang
HUEY-LING CHEN 
Keywords: antiviral agents; hepatitis B virus; infectious disease transmission; maternal-foetal relations; pregnancy
Issue Date: 2022
Publisher: WILEY
Journal Volume: 29
Journal Issue: 2
Start page/Pages: 107
Source: Journal of Viral Hepatitis
Abstract: 
Tenofovir disoproxil fumarate (TDF) is the preferred treatment to prevent mother-to-infant transmission in highly viremic HBV-infected women. Data on hepatitis B surface antigen (HBsAg) levels in pregnant women are lacking. We aimed to investigate prepartum and postpartum HBsAg kinetics and its correlation with HBV DNA in pregnant women. HBV-infected mothers with HBV DNA ≥7.5 log10  IU/ml were tested for HBsAg and HBV DNA from baseline to 6 months postpartum. Of the 186 pregnant women with comparable baseline HBsAg and HBV DNA, 101 received TDF from the third trimester until 1 month postpartum. At delivery, TDF group had mildly lower HBsAg (4.32 ± 0.47 vs. 4.54 ± 0.35 log10  IU/ml, p = .0004) and markedly lower HBV DNA (4.26 ± 0.97 vs. 8.11 ± 0.70 log10  IU/ml, p < .0001) than the control group. In the TDF group, mean reduction of HBsAg and HBV DNA from baseline to delivery were 0.22 ± 0.38 and 3.96 ± 0.93 log10  IU/ml. HBsAg reduction had a positive correlation (r = .309; p = .0017) with HBV DNA reduction, and was predictive of HBV DNA reduction ≥3 log10  IU/ml (area under the receiver operating characteristic curve, 0.67; 95% confidence interval, 0.50-0.82). At 6 months postpartum, TDF and control group had comparable HBsAg and HBV DNA. In conclusion, HBsAg decreased slightly at delivery in pregnant women receiving TDF. For monitoring the effect of antiviral therapy during pregnancy, HBV DNA is a better marker than HBsAg. Our data provided valuable information regarding monitoring HBV-infected pregnant women using antiviral therapy.
URI: https://scholars.lib.ntu.edu.tw/handle/123456789/595739
ISSN: 1352-0504
1365-2893
DOI: 10.1111/jvh.13628
SDG/Keyword: [SDGs]SDG3
antivirus agent; hepatitis B surface antigen; tenofovir; virus DNA; chronic hepatitis B; female; genetics; hepatitis B; Hepatitis B virus; human; infant; kinetics; pregnancy; pregnancy complication; pregnant woman; prevention and control; vertical transmi
Appears in Collections:醫學教育暨生醫倫理學科所

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