https://scholars.lib.ntu.edu.tw/handle/123456789/595761
標題: | Compound K inhibits priming and mitochondria-associated activating signals of NLRP3 inflammasome in renal tubulointerstitial lesions | 作者: | Hsu, Wan-Han Hua, Kuo-Feng Tuan, Li-Heng Tsai, Yu-Ling Chu, Lichieh Julie Lee, Yu-Chieh Wong, Wei-Ting Lee, Sheau-Long Lai, Jenn-Haung CHING-LIANG CHU Ho, Ling-Jun Chiu, Hsiao-Wen Hsu, Yu-Juei Chen, Cheng-Hsu Ka, Shuk-Man Chen, Ann |
關鍵字: | NLRP3 inflammasome; compound K; mechanically induced constant pressure; mitochondria; renal tubulointerstitial lesions | 公開日期: | 2020 | 出版社: | OXFORD UNIV PRESS | 卷: | 35 | 期: | 1 | 起(迄)頁: | 74 | 來源出版物: | Nephrology Dialysis Transplantation | 摘要: | Renal tubulointerstitial lesions (TILs), a key pathological hallmark for chronic kidney disease to progress to end-stage renal disease, feature renal tubular atrophy, interstitial mononuclear leukocyte infiltration and fibrosis in the kidney. Our study tested the renoprotective and therapeutic effects of compound K (CK), as described in our US patent (US7932057B2), on renal TILs using a mouse unilateral ureteral obstruction (UUO) model. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/595761 | ISSN: | 0931-0509 1460-2385 |
DOI: | 10.1093/ndt/gfz073 |
顯示於: | 免疫學研究所 |
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