Compound K inhibits priming and mitochondria-associated activating signals of NLRP3 inflammasome in renal tubulointerstitial lesions
Journal
Nephrology Dialysis Transplantation
Journal Volume
35
Journal Issue
1
Pages
74
Date Issued
2020
Author(s)
Hsu, Wan-Han
Hua, Kuo-Feng
Tuan, Li-Heng
Tsai, Yu-Ling
Chu, Lichieh Julie
Lee, Yu-Chieh
Wong, Wei-Ting
Lee, Sheau-Long
Lai, Jenn-Haung
Ho, Ling-Jun
Chiu, Hsiao-Wen
Hsu, Yu-Juei
Chen, Cheng-Hsu
Ka, Shuk-Man
Chen, Ann
Abstract
Renal tubulointerstitial lesions (TILs), a key pathological hallmark for chronic kidney disease to progress to end-stage renal disease, feature renal tubular atrophy, interstitial mononuclear leukocyte infiltration and fibrosis in the kidney. Our study tested the renoprotective and therapeutic effects of compound K (CK), as described in our US patent (US7932057B2), on renal TILs using a mouse unilateral ureteral obstruction (UUO) model.
Subjects
NLRP3 inflammasome; compound K; mechanically induced constant pressure; mitochondria; renal tubulointerstitial lesions
SDGs
Publisher
OXFORD UNIV PRESS
Type
journal article