|Title:||Correlation between early sublingual small vessel density and late blood lactate level in critically ill surgical patients||Authors:||Yeh Y.-C.
|Issue Date:||2013||Journal Volume:||180||Journal Issue:||2||Start page/Pages:||317-321||Source:||Journal of Surgical Research||Abstract:||
Background: Surgical stress may cause excessive inflammation and lead to microcirculatory dysfunction. The hypothesis of this study was that early microcirculatory dysfunction may result in anaerobic glycolysis and lead to elevated blood lactate levels in patients admitted to surgical intensive care units. Methods: This prospective observational study enrolled adult patients admitted to surgical intensive care units after general surgery or thoracic surgery. We measured blood lactate levels before the operation and at 1 h and 24 h after the operation. We obtained images of sublingual microcirculation using a sidestream dark field video microscope and analyzed them employing automated analysis software. Results: A total of 31 patients completed the study. Perioperative total and perfused small vessel densities were lower in patients with a blood lactate level ?3 mmol/L. We observed a significant correlation between the total small vessel density at 1 h and the blood lactate level at 24 h (r = -0.573; P = 0.001). In addition, we saw a significant correlation between the perfused small vessel density at 1 h and the blood lactate level at 24 h (r = -0.476; P = 0.008). Conclusions: Early total and perfused small vessel density may be used as an early predictor or therapeutic goal for critically ill surgical patients in further studies. ? 2013 Elsevier Inc. All rights reserved.
|ISSN:||0022-4804||DOI:||10.1016/j.jss.2012.05.006||SDG/Keyword:||lactic acid; adult; anaerobic glycolysis; article; capillary density; clinical article; critically ill patient; female; general surgery; human; intensive care unit; lactate blood level; male; mean arterial pressure; microcirculation; observational study; perioperative period; priority journal; prospective study; surgical patient; thorax surgery; Adult; Aged; Critical Illness; Female; Humans; Lactic Acid; Male; Microcirculation; Middle Aged; Mouth Floor; Prospective Studies; Surgical Procedures, Operative
|Appears in Collections:||醫學系|
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