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  4. Therapeutic development based on the immunopathogenic mechanisms of psoriasis
 
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Therapeutic development based on the immunopathogenic mechanisms of psoriasis

Journal
Pharmaceutics
Journal Volume
13
Journal Issue
7
Date Issued
2021-07-01
Author(s)
Tseng, Jen Chih
Chang, Yung Chi
Huang, Chun Ming
LI-CHUNG HSU  
Chuang, Tsung Hsien
DOI
10.3390/pharmaceutics13071064
URI
https://scholars.lib.ntu.edu.tw/handle/123456789/595886
URL
https://api.elsevier.com/content/abstract/scopus_id/85110873729
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110873729&doi=10.3390%2fpharmaceutics13071064&partnerID=40&md5=d37f119c89292d8ee72e1bd0fe77ff84
Abstract
Psoriasis, a complex inflammatory autoimmune skin disorder that affects 2–3% of the global population, is thought to be genetically predetermined and induced by environmental and immunological factors. In the past decades, basic and clinical studies have significantly expanded knowledge on the molecular, cellular, and immunological mechanisms underlying the pathogenesis of psoriasis. Based on these pathogenic mechanisms, the current disease model emphasizes the role of aberrant Th1 and Th17 responses. Th1 and Th17 immune responses are regulated by a complex network of different cytokines, including TNF-α, IL-17, and IL-23; signal transduction pathways downstream to the cytokine receptors; and various activated transcription factors, including NF-κB, interferon regulatory factors (IRFs), and signal transducer and activator of transcriptions (STATs). The biologics developed to specifically target the cytokines have achieved a better efficacy and safety for the systemic management of psoriasis compared with traditional treatments. Nevertheless, the current therapeutics can only alleviate the symptoms; there is still no cure for psoriasis. Therefore, the development of more effective, safe, and affordable therapeutics for psoriasis is important. In this review, we discussed the current trend of therapeutic development for psoriasis based on the recent discoveries in the immune modulation of the inflammatory response in psoriasis.
Subjects
Anti-psoriasis drugs | Autoimmune | Skin inflammation | Therapeutic antibody | Toll-like receptor
Publisher
MDPI
Type
review

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