https://scholars.lib.ntu.edu.tw/handle/123456789/596123
標題: | Impaired microcirculation after subarachnoid hemorrhage in an in vivo animal model | 作者: | KUO-CHUAN WANG SUNG-CHUN TANG Lee J.-E. JUI-CHANG TSAI DAR-MING LAI WEI-CHOU LIN CHIH-PENG LIN YONG-KWANG TU SUNG-TSANG HSIEH |
公開日期: | 1-十二月-2018 | 出版社: | Nature Publishing Group | 卷: | 8 | 期: | 1 | 起(迄)頁: | 13315 | 來源出版物: | Scientific Reports | 摘要: | The influence of aneurysmal subarachnoid hemorrhage (SAH) on brain microcirculation has not yet been systematically investigated. We established an animal model to examine (1) the brain surface microcirculation (2) the influences of cerebrospinal fluid (CSF) from aneurysmal SAH on the brain surface microcirculation. A rat SAH model was induced by injection of autologous arterial blood into the cisterna magnum, and the brain surface microcirculation was evaluated by a capillary videoscope with craniotomy at the fronto-parietal region. CSF from SAH rats and SAH patients was applied on the brain surface of naïve rats to assess the resulting microcirculatory changes. In the SAH rats, diffuse constriction of cortical arterioles within 24 hours of SAH was observed. Similar patterns of microcirculation impairment were induced on normal rat brain surfaces via application of CSF from SAH rats and SAH patients. Furthermore, the proportion of subjects with arteriolar vasoconstriction was significantly higher in the group of SAH patients with delayed ischemic neurological deficits (DIND) than in those without DIND (p < 0.001). This study demonstrated impaired microcirculation on brain surface arterioles in a rat model of SAH. CSF from SAH rats and patients was responsible for impairment of brain surface microcirculation. © 2018, The Author(s). |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85052974313&doi=10.1038%2fs41598-018-31709-7&partnerID=40&md5=3033d82a18f2693ce772ae204bc74344 https://scholars.lib.ntu.edu.tw/handle/123456789/596123 |
ISSN: | 2045-2322 | DOI: | 10.1038/s41598-018-31709-7 |
顯示於: | 病理學科所 |
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