https://scholars.lib.ntu.edu.tw/handle/123456789/596327
標題: | Paget's disease of the tibia | 作者: | Wang C.-L. CHEN-TU WU Chien C.-R. Hang Y.-H. |
關鍵字: | Alkaline phosphatase; Bone; Calcium; Epidemiology; Paget's disease | 公開日期: | 1999 | 卷: | 98 | 期: | 6 | 起(迄)頁: | 444-447 | 來源出版物: | Journal of the Formosan Medical Association | 摘要: | Paget's disease of the bone is perceived to be rare in Asia. We report the first documented case of Paget's disease of the bones in Taiwan. A 66- year-old native Taiwanese woman was admitted to hospital with a 10-year history of pain and a bowing deformity of her left leg. Laboratory data disclosed elevated serum calcium and alkaline phosphatase levels, but no leukocytosis. A plain X-ray film of the left leg showed a curved tibia with thickening of the tibial cortex, while a technetium 99m bone scan revealed abnormal uptake in the left tibia. Elevated serum levels of bone-specific alkaline phosphatase and urinary collagen N-telopeptide were also noted. Histologic examination of a biopsy specimen of the left tibia lesion confirmed the diagnosis of Paget's disease in the bone. The patient received treatment with sodium chlodronate, and the symptoms improved rapidly. Laboratory data then revealed decreased levels of serum calcium, bone- specific alkaline phosphatase, and urinary collagen N-telopeptide after treatment. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0032791510&partnerID=40&md5=e76fc2e20791d83adc0037a41ad3a9ca https://scholars.lib.ntu.edu.tw/handle/123456789/596327 |
ISSN: | 0929-6646 | SDG/關鍵字: | alkaline phosphatase bone isoenzyme; bisphosphonic acid derivative; calcium; sodium chlodronate; unclassified drug; aged; alkaline phosphatase blood level; article; bone radiography; calcium blood level; case report; clinical feature; female; follow up; histopathology; human; oral drug administration; Paget bone disease; tibia; treatment outcome; Aged; Asia; Asian Continental Ancestry Group; Female; Humans; Osteitis Deformans; Taiwan; Tibia |
顯示於: | 病理學科所 |
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