Paget's disease of the tibia
Journal
Journal of the Formosan Medical Association
Journal Volume
98
Journal Issue
6
Pages
444-447
Date Issued
1999
Author(s)
Abstract
Paget's disease of the bone is perceived to be rare in Asia. We report the first documented case of Paget's disease of the bones in Taiwan. A 66- year-old native Taiwanese woman was admitted to hospital with a 10-year history of pain and a bowing deformity of her left leg. Laboratory data disclosed elevated serum calcium and alkaline phosphatase levels, but no leukocytosis. A plain X-ray film of the left leg showed a curved tibia with thickening of the tibial cortex, while a technetium 99m bone scan revealed abnormal uptake in the left tibia. Elevated serum levels of bone-specific alkaline phosphatase and urinary collagen N-telopeptide were also noted. Histologic examination of a biopsy specimen of the left tibia lesion confirmed the diagnosis of Paget's disease in the bone. The patient received treatment with sodium chlodronate, and the symptoms improved rapidly. Laboratory data then revealed decreased levels of serum calcium, bone- specific alkaline phosphatase, and urinary collagen N-telopeptide after treatment.
Subjects
Alkaline phosphatase; Bone; Calcium; Epidemiology; Paget's disease
SDGs
Other Subjects
alkaline phosphatase bone isoenzyme; bisphosphonic acid derivative; calcium; sodium chlodronate; unclassified drug; aged; alkaline phosphatase blood level; article; bone radiography; calcium blood level; case report; clinical feature; female; follow up; histopathology; human; oral drug administration; Paget bone disease; tibia; treatment outcome; Aged; Asia; Asian Continental Ancestry Group; Female; Humans; Osteitis Deformans; Taiwan; Tibia
Type
journal article