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Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/596339
Title: Do immunosuppressants cause posttransplant diabetes mellitus?
Authors: CHEN-TU WU 
Wang W.-Y.
Lin S.-L.
Lee C.-J.
Keywords: immunosuppressant; posttransplant diabetes mellitus; renal transplantation
Issue Date: 1995
Journal Volume: 55
Journal Issue: 1
Start page/Pages: 37-41
Source: Chinese Medical Journal (Taipei)
Abstract: 
Background. Posttransplant diabetes mellitus (PTDM) was originally described by Starzl in 1964. The incidence is around 3-46%, according to several reports. Etiologies and risk factors of PTDM have been discussed after it was described and recognized as a complication of renal transplantation. Methods. Twenty-five consecutive renal transplants in 24 recipients were reviewed, and 3 cases of posttransplant diabetes mellitus were found. Cyclosporine A (CsA), Azathioprine (Aza) dose and maintenance dose of Prednisolone (Pred.), rejection episodes, total dosage of steroid used at the time of acute rejection were carefully recorded and analyzed. Results. The mean age of 3 living-related and 22 cadaveric transplant recipients was 32.7 ± 7.5 and 33.5 ± 6.8 years in PTDM and non-PTDM patients, and the onset of PTDM was, on the average, 11.3 ± 0.6 months. Comparative studies between non-PTDM and PTDM groups showed that age, rejection episodes, total dose of methylprednisolone used in acute rejection, CsA level, and dosage of CsA, Aza and prednisolone at 1, 6, 12 and 24 months were not significantly different from one another. Conclusions. No significant risk factors or definitive mechanism involved in the development of PTDM were identified in this study. It is suggested that immunosuppressants are involved in the occurrence of PTDM, and probably neither a single factor is responsible nor is dose dependency involved.
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0028964261&partnerID=40&md5=b40122ba1a4774abf311ba4fde58a4d5
https://scholars.lib.ntu.edu.tw/handle/123456789/596339
ISSN: 0578-1337
SDG/Keyword: azathioprine; cyclosporin; immunosuppressive agent; methylprednisolone; prednisolone; adult; article; clinical article; clinical trial; controlled clinical trial; controlled study; diabetes mellitus; female; graft rejection; human; kidney transplantation; male; oral drug administration; Adult; Diabetes Mellitus; Humans; Immunosuppressive Agents; Kidney Transplantation; Risk Factors
[SDGs]SDG3
Appears in Collections:病理學科所

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臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

總館學科館員 (Main Library)
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開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

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