https://scholars.lib.ntu.edu.tw/handle/123456789/596360
標題: | Effect of Epstein-Barr virus infection on global gene expression in nasopharyngeal carcinoma | 作者: | Lee Y.-C.G. Hwang Y.-C. Chen K.-C. Lin Y.-S. Huang D.-Y. Huang T.-W. Kao C.-Y. Wu H.-C. CHIN-TARNG LIN Huang C.-Y.F. |
關鍵字: | Epstein-Barr virus (EBV); Nasopharyngeal carcinoma (NPC); Quantitative real-time reverse transcriptase polymerase chain reaction (Q-RT-PCR); Transcriptomes | 公開日期: | 2007 | 卷: | 7 | 期: | 1 | 起(迄)頁: | 79-93 | 來源出版物: | Functional and Integrative Genomics | 摘要: | It was proposed that Epstein-Barr virus (EBV) is closely associated with nasopharyngeal carcinoma (NPC); however, the molecular mechanisms involved in the effect of EBV on NPC host genes have not yet been well defined. For this study, two sets of microarray experiments, NPC (EBV-free) vs normal epithelial cells and EBV+ vs EBV- NPC arrays, were analyzed and the datasets were cross-compared to identify any correlation between gene clusters involved in EBV targeting and the NPC host gene expression profiles. Statistical analysis revealed that EBV seems to have a preference for targeting more genes from the differentially expressed group in NPC cells than those from the ubiquitously expressed group. Furthermore, this trend is also reflected in log ratios where the EBV target genes of the differentially expressed group origin showed greater log ratios than genes with an origin from the ubiquitously expressed NPC group. Taken together, the genome-wide comparative scanning of EBV and NPC transcriptomes has successfully demonstrated that EBV infection has an intensifying effect on the signals involved in NPC gene expression both in breadth (the majority of the genes) and in depth (greater log ratios). ? Springer-Verlag 2006. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-33751547242&doi=10.1007%2fs10142-006-0035-2&partnerID=40&md5=f7efbb0c5c5d98dd6bdd3d3615e0a141 https://scholars.lib.ntu.edu.tw/handle/123456789/596360 |
ISSN: | 1438-793X | DOI: | 10.1007/s10142-006-0035-2 | SDG/關鍵字: | actin; binding protein; caspase 3; cell antigen; death associated protein kinase; midkine; Myc protein; myosin light chain; protein kinase C; somatomedin binding protein; syndecan; syntrophin; transcriptome; transforming growth factor beta1; animal cell; animal experiment; animal model; animal tissue; article; controlled study; correlation analysis; disease association; epithelium cell; Epstein Barr virus; gene cluster; gene expression; gene expression profiling; gene targeting; host; human; human cell; microarray analysis; molecular mechanics; mouse; nasopharynx carcinoma; nonhuman; nucleotide sequence; priority journal; reverse transcription polymerase chain reaction; signal transduction; statistical analysis; virus infection; Carcinoma; Cell Line; Cells, Cultured; Epstein-Barr Virus Infections; Gene Expression Regulation, Neoplastic; Herpesvirus 4, Human; Humans; Nasopharyngeal Neoplasms; Human herpesvirus 4 |
顯示於: | 病理學科所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。