https://scholars.lib.ntu.edu.tw/handle/123456789/596399
標題: | Omecamtiv mecarbil treatment improves post-resuscitation cardiac function and neurological outcome in a rat model | 作者: | Wu, Shih-Ni MIN-SHAN TSAI CHIEN-HUA HUANG WEN-JONE CHEN |
公開日期: | 2022 | 卷: | 17 | 期: | 2 | 來源出版物: | PloS one | 摘要: | Myocardial dysfunction is a major cause of poor outcomes in the post-cardiac arrest period. Omecamtiv mecarbil (OM) is a selective small molecule activator of cardiac myosin that prolongs myocardial systole and increases stroke volume without apparent effects on myocardial oxygen demand. OM administration is safe and improves cardiac function in patients with acute heart failure. Whether OM improves post-resuscitation myocardial dysfunction remains unclear. This study investigated the effect of OM treatment on post-resuscitation myocardial dysfunction and outcomes. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/596399 | ISSN: | 1932-6203 | DOI: | 10.1371/journal.pone.0264165 |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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