The serum concentrations of procollagen propeptides in hypertensive patients with or without diabetes
Journal
Acta Cardiologica Sinica
Journal Volume
24
Journal Issue
4
Pages
198-203
Date Issued
2008
Author(s)
Wang Y.-C.
Lin W.-C.
Liao L.-C.
Hsein Y.-C.
Abstract
Background: The serum concentrations of procollagen propeptides are valuable markers of myocardium collagen synthesis and turnover in hypertensive patients. The aim of our study was to evaluate the effect of diabetes mellitus on serum concentrations of procollagen propeptides in hypertensive patients. Methods: Sixty-three subjects admitted for coronary angiography were enrolled. All of the patients received analysis of the serum levels of the amino-terminal propeptide of types I and III procollagen (PINP and PIIINP). Results: Patients were divided into 3 groups according to the presence or absence of hypertension and diabetes; these were: 9 patients with both hypertension and diabetes (group 1), 38 patients with hypertension but without diabetes (group 2), and 16 normotensive patients without diabetes (group 3). Group 2 patients had higher serum PINP levels than group 1 and group 3 patients (p = 0.023 and p = 0.004, respectively). No significant difference of serum PINP level was noted between group 1 and group 3. However, the serum PIIINP level in group 1 patients was significantly higher than those in group 2 and group 3 (p = 0.005 and p < 0.001, respectively), and the serum PIIINP level between group 2 and group 3 showed no significant difference. Conclusion: Diabetic status influenced serum PINP and PIIINP levels differently in hypertensive patients.
SDGs
Other Subjects
PINP ； PIIINP ； Myocardial fibrosis ； Hypertension ； Diabetes mellitus
Type
journal article