https://scholars.lib.ntu.edu.tw/handle/123456789/596990
標題: | Study design and recruitment for a prospective controlled study of diabesity: Taiwan Diabesity Study | 作者: | Lee W.-J. YI-CHENG CHANG Almalki O. Chao S.-H. Lu C.H. Chen C.-C. Huang Y.-Y. Lee Y.-C. Hsu C.-C. |
關鍵字: | Bariatric surgery; Diabesity; Metabolic surgery; Obesity; Recruitment; Type 2 diabetes mellitus | 公開日期: | 2019 | 出版社: | Elsevier (Singapore) Pte Ltd | 卷: | 42 | 期: | 1 | 起(迄)頁: | 244-250 | 來源出版物: | Asian Journal of Surgery | 摘要: | Background: Strong evidence has shown that metabolic surgery is more effective than medical treatment in the treatment of type 2 diabetic patients. However, no study demonstrated a survival benefit and reduction of diabetes-related end-organ damage. Here, we describe the study design of a large prospective cohort study, the Taiwan Diabesity Study (TDS) which would compare the long-term survival rate and end-organ damage between overweight/obese type 2 diabetic patients receiving metabolic surgery and medical treatment. Methods: Eligibility criteria include type 2 diabetic patients with duration > 6 months, body mass index (BMI) over 25 kg/m 2 and age between 20 and 67 years. Exclusion criteria are serum creatinine over 2.0 mg/dL, C-peptide below 1.0 ng/ml, recent history of cancer, and major diabetic complications. Eligible participants were recruited from six medical centers in Taiwan. The survival rate and diabetes-related end organ damage will be compared between the metabolic surgery group and medical group after follow-up for 10 years. Results: In 3 years, 1016 participants were identified from 38,751 patients. The average BMI of patients was 30.6 (±2.6) kg/m 2 and the average hemoglobin A1c was 8.2% (±1.5%) with 18% of them receiving insulin treatment. Among them, 126 patients received metabolic surgery and 890 patients received conventional medical treatment. The metabolic surgery group are younger, have a higher proportion of females, higher BMI and blood lipids as compared to the medical group. Conclusion: The TDS recruited 1016 overweight/obese type 2 diabetic patients including 126 patients receiving metabolic surgery and 890 patients receiving medical treatment. ? 2018 |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85045001937&doi=10.1016%2fj.asjsur.2018.02.007&partnerID=40&md5=c6952bb6cac7284c0c5f4addc0db3dfa https://scholars.lib.ntu.edu.tw/handle/123456789/596990 |
ISSN: | 1015-9584 | DOI: | 10.1016/j.asjsur.2018.02.007 | SDG/關鍵字: | adult; aged; bariatric surgery; cohort analysis; comparative study; complication; diabetic complication; female; follow up; human; male; middle aged; mortality; non insulin dependent diabetes mellitus; obesity; prospective study; survival rate; Taiwan; time factor; young adult; Adult; Aged; Bariatric Surgery; Cohort Studies; Diabetes Complications; Diabetes Mellitus, Type 2; Female; Follow-Up Studies; Humans; Male; Middle Aged; Obesity; Prospective Studies; Survival Rate; Taiwan; Time Factors; Young Adult |
顯示於: | 基因體暨蛋白體醫學研究所 |
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