https://scholars.lib.ntu.edu.tw/handle/123456789/597253
標題: | The role of extracellular vesicles in prostate cancer with clinical applications | 作者: | Tai, Y.-L. Lin, C.-J. TSAI-KUN LI Shen, T.-L. Hsieh, J.-T. TANG-LONG SHEN |
公開日期: | 2020 | 出版社: | BioScientifica Ltd. | 卷: | 27 | 期: | 5 | 起(迄)頁: | R133-R144 | 來源出版物: | Endocrine-Related Cancer | 摘要: | In mammalian cells, extracellular vesicles (EVs) derived from the endosomal system carry many different kinds of bioactive molecule to deliver to recipient cells in a paracrine or endocrine manner. EVs can mediate local and systemic intercellular communications, including reeducating stromal cells, remodeling the architecture of the tumor microenvironment, modulating cancer metabolism and metastases, or even conferring drug resistance. Because the molecular and functional characteristics of prostate cancer (PCa) evolve over time, the bioactive molecule profiles/signatures of tumor-derived EVs (TDEs) reflect the real-time status of cancer cells. TDEs appear to be valuable diagnostic and prognostic biomarkers as well as potential therapeutic vehicles, suggesting their essential role in precision medicine of disease management. We summarized critical aspects of TDEs in PCa and discussed their potential clinical applications. ? 2020 Society for Endocrinology Published by Bioscientifica Ltd. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85089193724&doi=10.1530%2fERC-20-0021&partnerID=40&md5=5d1ceaad9c05ec1ccd4f60cd901e6619 https://scholars.lib.ntu.edu.tw/handle/123456789/597253 |
ISSN: | 1351-0088 | DOI: | 10.1530/ERC-20-0021 | SDG/關鍵字: | cancer patient; cancer resistance; cell lineage; cell plasticity; cell proliferation; exosome; human; male; prostate cancer; Review; tumor immunity; tumor microenvironment; urogenital tract metastasis; exosome; metabolism; prognosis; prostate tumor; tumor marker; Biomarkers, Tumor; Extracellular Vesicles; Humans; Male; Prognosis; Prostatic Neoplasms |
顯示於: | 微生物學科所 |
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