https://scholars.lib.ntu.edu.tw/handle/123456789/597485
標題: | Comparison of Various Solvent Extracts and Major Bioactive Components from Portulaca oleracea for Antioxidant, Anti-Tyrosinase, and Anti-α-Glucosidase Activities | 作者: | Chen, Wei Cheng Wang, Shih Wei Li, Cai Wei Lin, Hsiang Ru Yang, Chang Syun Chu, Yi Cheng TZONG-HUEI LEE Chen, Jih Jung |
關鍵字: | Anti-tyrosinase activity | Anti-α-glucosidase activity | Antioxidant activity | Major bioactive components | Portulaca oleracea | Various solvent extracts | 公開日期: | 1-二月-2022 | 出版社: | MDPI | 卷: | 11 | 期: | 2 | 起(迄)頁: | Article number 398 | 來源出版物: | Antioxidants | 摘要: | Portulaca oleracea is a well-known species for traditional medicine and food homology in Taiwan. In traditional medicine, P. oleracea is also used to treat gastrointestinal disorders, liver inflammation, fever, severe inflammation, and headaches. We investigated antioxidant, anti-tyrosinase, and anti-α-glucosidase activities of various solvent extracts and major bioactive components from P. oleracea. Ethanol and acetone extracts showed potent DPPH, ABTS, and hydroxyl radical scavenging activities. Chloroform and n-hexane extracts displayed significant superoxide radical scavenging activity. Furthermore, ethyl acetate and acetone extracts of P. oleracea showed potent anti-tyrosinase and anti-α-glucosidase activities. Examined and compared to the various solvent extracts for their chemical compositions using HPLC analysis, we isolated seven major compounds and analyzed their antioxidant, anti-tyrosinase, and anti-α-glucosidase activities. Seven active compounds of P. oleracea, especially quercetin, rosmarinic acid, and kaempferol, exhibited obvious antioxidant, anti-tyrosinase, and anti-α-glucosidase activities. The molecular docking model and the hydrophilic interactive mode of tyrosinase and α-glucosidase revealed that active compounds might have a higher antagonistic effect than commonly inhibitors. Our result shows that the active solvent extracts and their components of P. oleracea have the potential as natural antioxidants, tyrosinase and α-glucosidase inhibitors. Our results suggest that the active solvent extracts of P. oleracea and their components have potential as natural antioxidants, tyrosinase and α-glucosidase inhibitors. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/597485 | ISSN: | 20763921 | DOI: | 10.3390/antiox11020398 |
顯示於: | 漁業科學研究所 |
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