CTLA-4 gene mutation and multiple sclerosis: A case report and literature review
Journal
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi
Date Issued
2021-11-13
Author(s)
Abstract
We reported a patient with autoimmunity (multiple sclerosis), immunodeficiency (hypogammaglobulinemia with severe infections), enteropathy (diarrhea with intestinal inflammation), splenomegaly, lymphadenopathy and lymphocytic infiltration of non-lymphoid organs (lung, gut and brain). The patient was found to have a heterozygous mutation in cytotoxic T lymphocyte antigen-4, and had excellent response to abatacept.
Subjects
Abatacept; Cytotoxic T lymphocyte antigen-4; Multiple sclerosis; Primary immunodeficiency
SDGs
Type
journal article