https://scholars.lib.ntu.edu.tw/handle/123456789/598200
標題: | Fabrication of Low-Fouling Surfaces on Alkyne-Functionalized Poly-(p-xylylenes) Using Click Chemistry | 作者: | Chen P.-J Chen H.-Y HSIEN-YEH CHEN WEI-BOR TSAI |
關鍵字: | Anti-fouling;Chemical vapor deposition;Click chemistry;Poly-(p-xylylene);Polysulfobetaine;Thermo-responsive;Cell adhesion;Conjugated polymers;Fabrication;Hydrocarbons;Polyethylene glycols;Substrates;Anti-foulings;Chemical vapour deposition;Functionalized;Poly(p xylylene);Polysulfobetaines;Universal method;Versatile methods;Synthesis (chemical) | 公開日期: | 2022 | 卷: | 14 | 期: | 2 | 來源出版物: | Polymers | 摘要: | A facial, versatile, and universal method that breaks the substrate limits is desirable for an-tifouling treatment. Thin films of functional poly-p-xylylenes (PPX) that are deposited using chemical vapor deposition (CVD) provide a powerful platform for surface immobilization of molecules. In this study, we prepared an alkyne-functionalized PPX coating on which poly (sulfobetaine methacrylate-co-Az) could be conjugated via click chemistry. We found that the conjugated polymers were very stable and inhibited cell adhesion and protein adsorption effectively. The same conjugation strategy could also be applied to conjugate azide-containing poly (ethylene glycol) and poly (NIPAAm). The results indicate that our method provides a simple and robust tool for fabricating antifouling surfaces on a wide range of substrates using CVD technology of functionalized poly (p-xylylenes) for biosensor, diagnostics, immunoassay, and other biomaterial applications. ? 2022 by the authors. Licensee MDPI, Basel, Switzerland. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122318009&doi=10.3390%2fpolym14020225&partnerID=40&md5=26f4a0fc22c64ab41169e52f8f33ca07 https://scholars.lib.ntu.edu.tw/handle/123456789/598200 |
ISSN: | 20734360 | DOI: | 10.3390/polym14020225 |
顯示於: | 化學工程學系 |
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