https://scholars.lib.ntu.edu.tw/handle/123456789/598763
標題: | A Tri-Channel Oxide Transistor Concept for the Rapid Detection of Biomolecules Including the SARS-CoV-2 Spike Protein | 作者: | Liu C.-H Anthopoulos, Thomas D Han, Yang Sharma, Abhinav AlGhamdi, Wejdan S Liu, Chien-Hao Chang, Tzu-Hsuan Xiao, Xi-Wen Lin, Wei-Zhi Lu, Po-Yu Seitkhan, Akmaral Mottram, Alexander D Pattanasattayavong, Pichaya Faber, Hendrik Heeney, Martin Anthopoulos, Thomas D |
關鍵字: | Biomolecules;Chemical detection;Diseases;Electronic properties;Indium compounds;Metals;MOS devices;Oxide semiconductors;Proteins;Signal detection;Transistors;Analytes;Detection of biomolecules;Large-area electronics;Metal oxide semiconductor;Real-time detection;Severe acute respiratory syndrome coronavirus;Severe acute respiratory syndrome coronavirus 2;Solid-state devices;Solution process;Transistor sensors;Heterojunctions;ACE2 protein, human;coronavirus spike glycoprotein;DNA;immobilized antibody;indium;indium oxide;spike protein, SARS-CoV-2;virus antibody;zinc oxide;bioengineering;blood;chemistry;computer simulation;computer system;devices;diagnosis;equipment design;genetic procedures;human;immunology;metabolism;microtechnology;procedures;proof of concept;transistor;virology;Angiotensin-Converting Enzyme 2;Antibodies, Immobilized;Antibodies, Viral;Bioengineering;Biosensing Techniques;Computer Simulation;Computer Systems;COVID-19;COVID-19 Testing;Equipment Design;Humans;Indium;Microtechnology;Proof of Concept Study;SARS-CoV-2;Spike Glycoprotein, Coronavirus;Transistors, Electronic;Zinc Oxide | 公開日期: | 2022 | 卷: | 34 | 期: | 3 | 來源出版物: | Advanced Materials | 摘要: | Solid-state transistor sensors that can detect biomolecules in real time are highly attractive for emerging bioanalytical applications. However, combining upscalable manufacturing with the required performance remains challenging. Here, an alternative biosensor transistor concept is developed, which relies on a solution-processed In2O3/ZnO semiconducting heterojunction featuring a geometrically engineered tri-channel architecture for the rapid, real-time detection of important biomolecules. The sensor combines a high electron mobility channel, attributed to the electronic properties of the In2O3/ZnO heterointerface, in close proximity to a sensing surface featuring tethered analyte receptors. The unusual tri-channel design enables strong coupling between the buried electron channel and electrostatic perturbations occurring during receptor–analyte interactions allowing for robust, real-time detection of biomolecules down to attomolar (am) concentrations. The experimental findings are corroborated by extensive device simulations, highlighting the unique advantages of the heterojunction tri-channel design. By functionalizing the surface of the geometrically engineered channel with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody receptors, real-time detection of the SARS-CoV-2 spike S1 protein down to am concentrations is demonstrated in under 2 min in physiological relevant conditions. ? 2021 Wiley-VCH GmbH |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119276498&doi=10.1002%2fadma.202104608&partnerID=40&md5=9ef265f6875915e3aec5cb8c10fe6e9b https://scholars.lib.ntu.edu.tw/handle/123456789/598763 |
ISSN: | 09359648 | DOI: | 10.1002/adma.202104608 |
顯示於: | 機械工程學系 |
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