Mathematical modelling of haemorrhagic transformation after ischaemic stroke
Journal
Journal of Theoretical Biology
Journal Volume
531
Date Issued
2021
Author(s)
Wang J
Abstract
With an increasingly elderly population globally, the impacts of cerebrovascular diseases, such as stroke and dementia, become increasingly significant. Haemorrhagic transformation (HT) is one of the most common complications of ischaemic stroke that is caused by dysfunction of endothelial cells in the blood–brain barrier (BBB) and that can be exacerbated by thrombolytic therapy. Recent studies also suggest that HT can lead to an increase in intracranial pressure (ICP) and result in capillary compression. The aim of this study is to develop a mathematical model that can be used to simulate the consequence of HT over a range of vasculature length scales. We use a 2D vasculature model to investigate the severity of HT with different vascular geometry. The resulting model shows that the haematoma radius is approximately constant across different length scales (100-1000μm) and in good agreement with the available experimental data. In addition, this study identified that the effects of capillary compression do appear to have a significant impact on the leakage fraction of blood and hence act to restrain the development of a haematoma. ? 2021 Elsevier Ltd
Subjects
Capillary compression
Haematoma volume
Haemorrhagic transformation
blood
elderly population
numerical model
public health
stroke
tissue plasminogen activator
aged
brain hemorrhage
brain ischemia
cerebrovascular accident
complication
endothelium cell
human
theoretical model
Aged
Brain Ischemia
Cerebral Hemorrhage
Endothelial Cells
Humans
Ischemic Stroke
Models, Theoretical
Stroke
Tissue Plasminogen Activator
SDGs
Type
journal article