https://scholars.lib.ntu.edu.tw/handle/123456789/598854
Title: | Quantitative 3D analysis of tissue damage in a rat model of microembolization | Authors: | Payne S. van der Wijk A.-E. Bakker E.N.T.P. vanBavel E. Majoie C. Marquering H. van Bavel E. Hoekstra A. Dippel D. Lingsma H. van der Lugt A. Samuels N. Boodt N. Roos Y. de Meyer S. Staessens S. Vandelanotte S. Konduri P. Terreros N.A. Chopard B. Raynaud F. Petkantchin R. Panteleev M. Shibeko A. Boudjeltia K.Z. Blanc-Guillemaud V. Migliavacca F. Dubini G. Luraghi G. Matas J.F.R. Bridio S. Mc Garry P. Gilvarry M. McCarthy R. Moerman K. Fereidoonnezhad B. Dwivedi A. Duffy S. Payne S. Jozsa T. Georgakopoulou S. Padmos R. Azizi V. Miller C. STEPHEN JOHN PAYNE |
Keywords: | Endovascular therapy;Hypoxia;Incomplete microvascular reperfusion;Microembolization;Spatial analysis;Stroke;Blood vessels;Hemodynamics;Patient treatment;Spatial variables measurement;Three dimensional computer graphics;Tissue;Endovascular;Microemboli;Microvascular;Reperfusion;Rats;animal;brain;brain ischemia;cerebrovascular accident;endovascular surgery;human;internal carotid artery;rat;treatment outcome;Animals;Brain;Brain Ischemia;Carotid Artery, Internal;Endovascular Procedures;Humans;Treatment Outcome | Issue Date: | 2021 | Journal Volume: | 128 | Source: | Journal of Biomechanics | Abstract: | There is a discrepancy between successful recanalization and good clinical outcome after endovascular treatment (EVT) in acute ischemic stroke patients. During removal of a thrombus, a shower of microemboli may release and lodge to the distal circulation. The objective of this study was to determine the extent of damage on brain tissue caused by microemboli. In a rat model of microembolization, a mixture of microsphere (MS) sizes (15, 25 and 50 ?m diameter) was injected via the left internal carotid artery. A 3D image of the left hemisphere was reconstructed and a point-pattern spatial analysis was applied based on G- and K-functions to unravel the spatial correlation between MS and the induced hypoxia or infarction. We show a spatial correlation between MS and hypoxia or infarction spreading up to a distance of 1000–1500 ?m. These results imply that microemboli, which individually may not always be harmful, can interact and result in local areas of hypoxia or even infarction when lodged in large numbers. ? 2021 The Authors |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114684544&doi=10.1016%2fj.jbiomech.2021.110723&partnerID=40&md5=335e85319ea0cd3b977864512c6964d2 https://scholars.lib.ntu.edu.tw/handle/123456789/598854 |
ISSN: | 00219290 | DOI: | 10.1016/j.jbiomech.2021.110723 |
Appears in Collections: | 應用力學研究所 |
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