https://scholars.lib.ntu.edu.tw/handle/123456789/598883
標題: | Coupling one-dimensional arterial blood flow to three-dimensional tissue perfusion models for in silico trials of acute ischaemic stroke: Coupling Blood Flow to Perfusion | 作者: | Padmos R.M J?zsa T.I El-Bouri W.K Konduri P.R Payne S.J STEPHEN JOHN PAYNE |
關鍵字: | acute ischaemic stroke;cerebral perfusion;one-dimensional blood flow model;perfusion territories;Blood;Blood vessels;Brain;Interface states;Tissue;Acute ischemic stroke;Arterial blood;Blood flow;Blood flow modeling;Cerebral perfusion;One-dimensional;One-dimensional blood flow model;Perfusion models;Perfusion territory;Tissue perfusion;Hemodynamics | 公開日期: | 2021 | 卷: | 11 | 期: | 1 | 來源出版物: | Interface Focus | 摘要: | An acute ischaemic stroke is due to the sudden blockage of an intracranial blood vessel by an embolized thrombus. In the context of setting up in silico trials for the treatment of acute ischaemic stroke, the effect of a stroke on perfusion and metabolism of brain tissue should be modelled to predict final infarcted brain tissue. This requires coupling of blood flow and tissue perfusion models. A one-dimensional intracranial blood flow model and a method to couple this to a brain tissue perfusion model for patient-specific simulations is presented. Image-based patient-specific data on the anatomy of the circle of Willis are combined with literature data and models for vessel anatomy not visible in the images, to create an extended model for each patient from the larger vessels down to the pial surface. The coupling between arterial blood flow and tissue perfusion occurs at the pial surface through the estimation of perfusion territories. The coupling method is able to accurately estimate perfusion territories. Finally, we argue that blood flow can be approximated as steady-state flow at the interface between arterial blood flow and tissue perfusion to reduce the cost of organ-scale simulations. ? 2020 The Authors. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099500236&doi=10.1098%2frsfs.2019.0125rsfs20190125&partnerID=40&md5=c7b3aeee0855cd87ba7bf786b5456a26 https://scholars.lib.ntu.edu.tw/handle/123456789/598883 |
ISSN: | 20428898 | DOI: | 10.1098/rsfs.2019.0125rsfs20190125 |
顯示於: | 應用力學研究所 |
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