https://scholars.lib.ntu.edu.tw/handle/123456789/598988
標題: | The synthesis and evaluation of RGD?conjugated chitosan gel as daily supplement for body weight control | 作者: | Chen W.-Y Chen Y.-T Ke C.-J Chen C.-Y Lin F.-H. Lin, Feng-Huei |
關鍵字: | Chitosan;Highly biocompatibility;Obesity;RGD;Type 2 diabetes;Anthropometry;Biocompatibility;Diseases;Nuclear magnetic resonance spectroscopy;Nutrition;Peptides;Weight control;Adverse effect;Chitosan gel;Chronic disease;FTIR and NMR spectra;Medical Devices;Small intestine;Type-2 diabetes;Visceral fat | 公開日期: | 2021 | 卷: | 14 | 期: | 16 | 來源出版物: | Materials | 摘要: | (1) Background: Obesity is one of the most widespread chronic diseases and increases the risk of several other chronic diseases, especially type 2 diabetes. (2) Methods: Endobarrier is a new medical device what is worn in the small intestines for the treatment of type 2 diabetes and obesity. However, given the invasive and other adverse effects of the Endobarrier, we propose the use of RGD peptide conjugated with chitosan (RC) as an alternative. (3) Results: The FTIR and NMR spectrum showed RGD peptide was successfully conjugated on chitosan and RGD?CT is retained in the small intestine even after digestion. In vitro of wst-1 and live and dead staining studies show that the RGD?CT gel is highly biocompatible and non-toxic. Rats treated with the RGD?CT gel for a short term showed significant decrease change more than 30% in body weight, while the blood and hematic biometrics were within normal values. (4) Conclusions: The RGD?CT gel is safe, suitable for the short-term, reducing visceral fat rate health food to control weight. In the future, it is expected to develop a safe, long-term effective, flexibility of use and low-side-effect anti-obesity therapy in the era of precision medicine by further modification. ? 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112496600&doi=10.3390%2fma14164467&partnerID=40&md5=663ec646b34185f56f6cebb439975a80 https://scholars.lib.ntu.edu.tw/handle/123456789/598988 |
ISSN: | 19961944 | DOI: | 10.3390/ma14164467 |
顯示於: | 醫學工程學研究所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。