https://scholars.lib.ntu.edu.tw/handle/123456789/599014
標題: | Enhancement of rotator cuff healing with farnesol-impregnated gellan gum/hyaluronic acid hydrogel membranes in a rabbit model | 作者: | Lin Y.-H Lee S.-I Lin F.-H Wu G.-X Wu C.-S Kuo S.-M. Lin, Feng-Huei |
關鍵字: | Collagen synthesis;Farnesol;Hyaluronan;Hydrogel membranes;Rotator cuff tendon tears;farnesol;gellan;hyaluronic acid;hydrogel;interleukin 6;tumor necrosis factor;animal experiment;animal model;animal tissue;antioxidant assay;Article;biocompatibility;bone regeneration;cell migration;cell viability;collagen fiber density;collagen fiber orientation;controlled study;cytotoxicity;drug release;extracellular matrix;fluorescence microscopy;histology;histopathology;Leporidae;male;MTT assay;myoblast;nonhuman;optical coherence tomography;osseointegration;rotator cuff;rotator cuff injury;rotator cuff rupture;scanning electron microscopy;swelling test;tendon bone interface;tenocyte;tissue engineering;tissue regeneration;water content | 公開日期: | 2021 | 卷: | 13 | 期: | 7 | 來源出版物: | Pharmaceutics | 摘要: | Most rotator cuff (RC) tears occur at the bone–tendon interface and cause disability and pain. Farnesol, a sesquiterpene compound, can exert antioxidative and anti-inflammatory effects and promote collagen synthesis. In this rabbit model, either commercial SurgiWrap membrane or hydrogel membranes containing various compositions of gellan gum, hyaluronic acid, and farnesol (hereafter GHF membranes) were applied to the tear site, and the repair of the cuff was examined 2 and 3 weeks afterward. The designed membranes swelled rapidly and adsorbed onto the tear site more readily and closely than the SurgiWrap membrane. The membranes degraded slowly and functioned as both a barrier and a vehicle of slow farnesol release during the repair period. Farnesol enhanced collagen production in myoblasts and tenocytes, and interleukin 6 and tumor necrosis factor α levels were modulated. Gross observations and histological examinations indicated that the GHF membranes impregnated with 4 mM farnesol resulted in superior RC repair. In sum, the slow release of farnesol from hydrogel membranes can be beneficial in the repair of RC injuries. ? 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109169398&doi=10.3390%2fpharmaceutics13070944&partnerID=40&md5=8304637862de4a6a5592413e094cbd25 https://scholars.lib.ntu.edu.tw/handle/123456789/599014 |
ISSN: | 19994923 | DOI: | 10.3390/pharmaceutics13070944 |
顯示於: | 醫學工程學研究所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。