New cyclic peptides from the seeds of Annona squamosa L. and their anti-inflammatory activities
Journal
Journal of Agricultural and Food Chemistry
Journal Volume
56
Journal Issue
2
Pages
386-392
Date Issued
2008
Author(s)
Abstract
Two new cyclic peptides, cyclosquamosin H (1) and I (2), together with six known cyclic peptides, squamin A (3), squamin B (4), cyclosquamosin A (6), cyclosquamosin D (7), cyclosquamosin E (8), and cherimolacyclopeptide B (9), were isolated from the seeds of Annona squamosa. All structures were confirmed by 2D nuclear magnetic resonance, chemical evidence, and electrospray ionization-mass spectromotry/mass spectrometry (ESI-MS/MS). Compound 9 was isolated from this plant for the first time. In the anti-inflammatory assay, compound 7 showed an inhibitory effect on the production of pro-inflammatory cytokines within lipopolysaccharide and Pam3Cys-stimulated J774A.1 macrophages. © 2008 American Chemical Society.
SDGs
Type
journal article