A radiomics model can distinguish solitary pulmonary capillary haemangioma from lung adenocarcinoma
Journal
Interactive cardiovascular and thoracic surgery
Journal Volume
34
Journal Issue
3
Pages
369
Date Issued
2022
Author(s)
Wang, Hao-Jen
Chen, Yi-Chang
Chen, Li-Wei
Chen, Ho-Feng
Wang, Chuan-Wei
Abstract
Objectives: Solitary pulmonary capillary haemangioma (SPCH) is a benign lung tumour that presents as ground-glass nodules on computed tomography (CT) images and mimics lepidic-predominant adenocarcinoma. This study aimed to establish a discriminant model using a radiomic feature analysis to distinguish SPCH from lepidic-predominant adenocarcinoma.
Methods: In the adenocarcinoma group, all tumours were of the lepidic-predominant subtype with high purity (>70%). A classification model was proposed based on a two-level decision tree and 26 radiomic features extracted from each segmented lesion. For comparison, a baseline model was built with the same 26 features using a support vector machine as the classifier. Both models were assessed by the leave-one-out cross-validation method.
Results: This study included 13 and 49 patients who underwent complete resection for SPCH and adenocarcinoma, respectively. Two sets of features were identified for discrimination between the 2 different histology types. The first set included 2 principal components corresponding to the 2 largest eigenvalues for the root node of the two-level decision tree. The second set comprised 4 selected radiomic features. The area under the receiver operating characteristic curve, accuracy, sensitivity, specificity were 0.954, 91.9%, 92.3% and 91.8% in the proposed classification model, and were 0.805, 85.5%, 61.5% and 91.8% in the baseline model, respectively. The proposed classification model significantly outperformed the baseline model (P < 0.05).
Conclusions: The proposed model could differentiate the 2 different histology types on CT images, and this may help surgeons to preoperatively discriminate SPCH from adenocarcinoma.
Subjects
Computed tomography
Ground-glass nodule
Lung adenocarcinoma
Lung cancer surgery
Solitary pulmonary capillary haemangioma
Publisher
OXFORD UNIV PRESS
Type
journal article