https://scholars.lib.ntu.edu.tw/handle/123456789/604935
標題: | Concurrent analysis of copy number variation and gene expression: Application in paired non-smoking female lung cancer patients | 作者: | Chen, P.-C. TZU-PIN LU Chang, J.-C. LIANG-CHUAN LAI MONG-HSUN TSAI CHUHSING KATE HSIAO ERIC YAO-YU CHUANG |
公開日期: | 2013 | 出版社: | Inderscience Publishers | 卷: | 8 | 期: | 1 | 起(迄)頁: | 92-104 | 來源出版物: | International Journal of Data Mining and Bioinformatics | 摘要: | Recent studies indicate that both genomic alterations and transcriptional dysregulation influence the disease progresses. This study proposes a method identifying pathways by integrating copy numbers (CN), gene expressions (GE) and their correlations. A lung cancer patients dataset with both normal and tumor tissues is utilized to evaluate the performance of the proposed method. To further appraise the predicting abilities of those pathways, these patients are classified by support vector machines. Based on the classification results, pathways integrating CN, GE and their correlations is more informative and biologically meaningful and perform better than pathways obtained by only CN or only GE. Copyright © 2013 Inderscience Enterprises Ltd. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84879679944&doi=10.1504%2fIJDMB.2013.054699&partnerID=40&md5=6bead200830b94572680dd41fbd62c2d https://scholars.lib.ntu.edu.tw/handle/123456789/604935 |
ISSN: | 17485673 | DOI: | 10.1504/IJDMB.2013.054699 | SDG/關鍵字: | CN; Concurrent analysis; Copy number; GE; Gene expression; Gene set enrichment analysis; Pathways; Support vector machine |
顯示於: | 流行病學與預防醫學研究所 |
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