https://scholars.lib.ntu.edu.tw/handle/123456789/605857
標題: | Preventive Effects of Lactobacillus Mixture against Chronic Kidney Disease Progression through Enhancement of Beneficial Bacteria and Downregulation of Gut-Derived Uremic Toxins | 作者: | Huang H Li K Lee Y MING-JU CHEN YA-JANE LEE |
關鍵字: | chronic kidney disease;gut dysbiosis;gut-derived uremic toxins;Lactobacillus;probiotic screening platform;Bacilli;Diagnosis;Metabolites;Volatile fatty acids;Chronic kidney disease;Immune response;Intestinal barriers;Lactobacillus plantarum;Metabolite production;Microbial composition;Proinflammatory;Short-chain fatty acids;Probiotics;probiotic agent;animal;bacterium;chronic kidney failure;disease exacerbation;down regulation;intestine flora;mouse;Animals;Bacteria;Disease Progression;Down-Regulation;Gastrointestinal Microbiome;Mice;Renal Insufficiency, Chronic | 公開日期: | 2021 | 卷: | 69 | 期: | 26 | 起(迄)頁: | 7353-7366 | 來源出版物: | Journal of Agricultural and Food Chemistry | 摘要: | Gut dysbiosis is a major contributor to adverse chronic kidney disease (CKD) progression, and microbiota-based strategies could be considered as a novel therapeutic and preventative target. In this study, a probiotic screening platform based on gut-derived uremic toxin-reducing probiotics was developed and the underlying mechanism was further verified through a 0.2% adenine-induced CKD mouse model. Two strains (Lactobacillus paracasei and Lactobacillus plantarum) were selected due to their high clearance ability and named Lactobacillus mix (Lm). The results showed that Lm significantly improved the kidney function by reducing kidney injury and fibrotic-related proteins. Furthermore, Lm decreased oxidative stress and proinflammatory reactions and elevated immune responses in the kidney. Importantly, Lm reversed gut dysbiosis and restored the abundance of commensal bacteria, especially short-chain fatty acid producers, leading to improved intestinal barrier integrity via modulation of microbial composition and metabolite production. Taken together, these findings provided evidence that Lm could be a preventive approach against CKD. ? 2021 American Chemical Society. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110258535&doi=10.1021%2facs.jafc.1c01547&partnerID=40&md5=5386876741f7f86e93a97658cb92f5f6 https://scholars.lib.ntu.edu.tw/handle/123456789/605857 |
ISSN: | 00218561 | DOI: | 10.1021/acs.jafc.1c01547 |
顯示於: | 動物科學技術學系 |
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