https://scholars.lib.ntu.edu.tw/handle/123456789/605972
標題: | Hericium erinaceus mycelium ameliorate anxiety induced by continuous sleep disturbance in vivo | 作者: | Li T.-J Lee T.-Y Lo Y Lee L.-Y Li I.-C Chen C.-C FANG-CHIA CHANG |
關鍵字: | Anxiety;COVID-19;Hericium erinaceus mycelium;NREM;Sleep;fungal extract;Hericium erinaceus mycelium extract;neuroprotective agent;unclassified drug;biological product;animal experiment;animal model;animal tissue;antidepressant activity;anxiety;Article;chemiluminescence immunoassay;controlled study;coronavirus disease 2019;dopamine blood level;electroencephalogram;electromyogram;elevated plus maze test;enzyme linked immunosorbent assay;experimental behavioral test;Hericium erinaceus;in vivo study;mouse;mycelium;neuroprotection;nonhuman;nonREM sleep;open field test;polyacrylamide gel electrophoresis;REM sleep;sensitivity analysis;signal transduction;sleep disorder;tail suspension test;Western blotting;animal;C57BL mouse;disease model;drug effect;Hericium;metabolism;sleep;Animals;Biological Products;Disease Models, Animal;Mice;Mice, Inbred C57BL;Mycelium;Sleep Wake Disorders | 公開日期: | 2021 | 卷: | 21 | 期: | 1 | 來源出版物: | BMC Complementary Medicine and Therapies | 摘要: | Background: Sleep disruption is a major public health issue and may increase the risk of mortality by ten-folds if an individual is sleeping less than 6 h per night. Sleep has changed dramatically during to the COVID-19 pandemic because COVID symptoms can lead to psychological distress including anxiety. Hericium erinaceus mycelium has been widely investigated in both the in vivo studies and clinical trials for its neuroprotective functions because the mycelium contains hericenones and erinacines, which synthesize the nerve growth factor and brain-derived neurotrophic factor (BDNF). Recent in vivo reports have shown showed that erinacine A-enriched Hericium erinaceus mycelium can modulate BDNF/TrkB/PI3K/Akt/GSK-3β pathways to induce an antidepressant-like effect. A large body of evidence indicates that erinacine can pass the blood-brain barrier and suggests its neuroprotective function in both peripheral and central nervous systems. Thus, Hericium erinaceus mycelium may be a dual-function supplement for sleep disruption improvement while sustaining anxiolytic effects. Method: To simulate the condition of sleep disruption, the mice were subjected to the tail suspension test (TST) for 15 min every day during the same period for nine consecutive days. Two different doses (75 and 150 mg/kg) of Hericium erinaceus mycelium were administered orally 20 min prior to the TSTs before entering the light period of 12:12 h L:D cycle. All sleep-wake recording was recorded for 24 h using electroencephalogram and electromyogram. The elevated-plus-maze and open-field tests were conducted to record the behavior activities. Results: Consecutive TSTs prior to the light period could cause significant sleep disturbance and anxiety behavior in the elevated-plus-maze experiments. Results showed that administration with Hericium erinaceus mycelium at 150 mg/kg ameliorated the rodent anxiety (p < 0.05) and reversed the TST-induced NREM sleep disturbance in the dark period. Conclusion: This is the first in vivo study suggesting that Hericium erinaceus mycelium has a dual potential role for anxiety relief through improving sleep disruptions. ? 2021, The Author(s). |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120733920&doi=10.1186%2fs12906-021-03463-3&partnerID=40&md5=8ceecd1079a824adab06a1966a8da093 https://scholars.lib.ntu.edu.tw/handle/123456789/605972 |
ISSN: | 26627671 | DOI: | 10.1186/s12906-021-03463-3 |
顯示於: | 獸醫學系 |
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