https://scholars.lib.ntu.edu.tw/handle/123456789/606141
標題: | Pterostilbene Attenuates High-Fat Diet and Dextran Sulfate Sodium-Induced Colitis via Suppressing Inflammation and Intestinal Fibrosis in Mice | 作者: | Fan-Jiang P.-Y Lee P.-S Nagabhushanam K Ho C.-T MIN-HSIUNG PAN |
關鍵字: | colitis;dextran sulfate sodium (DSS);high-fat diet (HFD);intestinal fibrosis;pterostilbene (PTS);Dextran;Mammals;Nutrition;Pathology;Potable water;Sodium;Sulfur compounds;Dextran sulfate sodium;Dextran sulfate sodium (DSS) induced colitis;E-cadherin expression;Homologous proteins;Inflammatory bowel disease;Matrix metalloproteinase-2;Naturally occurring;Transforming growth factor beta;Diseases;dextran sulfate;gelatinase A;pterostilbene;stilbene derivative;adverse event;animal;C57BL mouse;colon;disease model;fibrosis;genetics;inflammation;lipid diet;mouse;pathology;Animals;Colitis;Colon;Dextran Sulfate;Diet, High-Fat;Disease Models, Animal;Fibrosis;Inflammation;Matrix Metalloproteinase 2;Mice;Mice, Inbred C57BL;Stilbenes | 公開日期: | 2021 | 卷: | 69 | 期: | 25 | 起(迄)頁: | 7093-7103 | 來源出版物: | Journal of Agricultural and Food Chemistry | 摘要: | The worldwide prevalence of obesity has significantly increased over the past few decades. It is currently believed that obesity is a risk factor for developing inflammatory bowel disease. Pterostilbene (PTS), a naturally occurring stilbene from blueberries, is known to have anticancer, anti-inflammation, antifibrosis, and antiobesity effects. The preventive effect of PTS on the susceptibility of high-fat diet (HFD) to dextran sulfate sodium (DSS)-induced colitis in mice was investigated. Beginning at 5 weeks of age, C57BL/6J mice were fed a normal diet, 50% HFD alone, or containing PTS, and DSS (2.5%, w/v) was given in drinking water at week 9 and week 11. The results demonstrated that PTS significantly attenuated HFD and DSS-induced plasma interleukin-6 accumulation. Moreover, PTS suppressed HFD/DSS-induced formation of aberrant crypt foci and reduced the colon weight-to-length ratio in HFD/DSS-induced colitis mice. Furthermore, PTS inhibited interleukin-1β (IL-1β), the C/EBP homologous protein (CHOP), cyclooxygenase-2, and transforming growth factor beta-1 (TGF-β1)/mothers against decapentaplegic homolog 2 expression and maintained mucin2 (Muc2) and E-cadherin expressions. In addition, post-treatment with PTS also decreased the colon weight-to-length ratio and loss of Muc2. Moreover, the CHOP, IL-1β, matrix metalloproteinase-2, and TGF-β1 expressions were significantly decreased in HFD/DSS-induced colitis mice after post-treatment with PTS. In conclusion, the results of the present study suggest that PTS is of significant interest for the prevention of HFD/DSS-induced colitis in C57BL/6J mice. ? |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110243208&doi=10.1021%2facs.jafc.1c02783&partnerID=40&md5=a53002f489ab492ff45582a03b5217e1 https://scholars.lib.ntu.edu.tw/handle/123456789/606141 |
ISSN: | 00218561 | DOI: | 10.1021/acs.jafc.1c02783 |
顯示於: | 食品科技研究所 |
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