https://scholars.lib.ntu.edu.tw/handle/123456789/606146
標題: | Dietary Pterostilbene and Resveratrol Modulate the Gut Microbiota Influenced by Circadian Rhythm Dysregulation | 作者: | Koh Y.-C Lee P.-S Kuo Y.-L Nagabhushanam K Ho C.-T MIN-HSIUNG PAN |
關鍵字: | chronic jetlag;circadian rhythm;gut microbiota;pterostilbene;resveratrol | 公開日期: | 2021 | 卷: | 65 | 期: | 21 | 來源出版物: | Molecular Nutrition and Food Research | 摘要: | Scope: A causal relationship between circadian misalignment and microbiota dysbiosis has been discussed recently, due to their association to pathogenesis. Herein, the possible impact of pterostilbene (PSB) and resveratrol (RES) on the gut microbiota brought by chronic jet-lag in mice is investigated. Methods and Results: Dietary supplement of RES and PSB (0.25%) are given to 16 week-jetlagged mice to examine the effects on microbiota and physiological functions. Jetlag significantly induces weight gained that could be effectively prevented by PSB. Both supplements also retain oscillation patterns that found to be lost in jetlag induced (JLG) group, including serum biochemical parameters and gut microbiota. The results of beta diversity suggest the supplementations efficiently lead to distinct gut microbial composition as compared to JLG group. Besides, the supplementation forestalls some microbial elevation, such as Eubacterium ventriosum and Acetitomaculum. Growth of health beneficial bacteria like Blautia and Lachnospiraceae UCG-001 is facilitated and abundance of these bacteria could be correlated to oscillation of biochemical parameters. Result of KEGG indicates distinct effect brought by microbial re-shaping. Conclusion: The result suggests that supplementation of RES and PSB could potentially dampen some adverse effects of gut microbiota dysbiosis, and at the same time, re-composite and facilitate the growth of health beneficial microbiota. ? 2021 Wiley-VCH GmbH |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117042567&doi=10.1002%2fmnfr.202100434&partnerID=40&md5=d9a53d7b8590c0e9c99afcce1b8ef682 https://scholars.lib.ntu.edu.tw/handle/123456789/606146 |
ISSN: | 16134125 | DOI: | 10.1002/mnfr.202100434 |
顯示於: | 食品科技研究所 |
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