https://scholars.lib.ntu.edu.tw/handle/123456789/606149
標題: | Calebin-A prevents HFD-induced obesity in mice by promoting thermogenesis and modulating gut microbiota | 作者: | Lee P.-S Lu Y.-Y Nagabhushanam K Ho C.-T Mei H.-C MIN-HSIUNG PAN |
關鍵字: | Anti-Obesity;Calebin A;Gut microbiota;Obesity;Thermogenesis | 公開日期: | 2022 | 來源出版物: | Journal of Traditional and Complementary Medicine | 摘要: | Background and aim: Obesity is one of the complications of sedentary lifestyle and high-calorie food intake which become a global problem. Thermogenesis is a novel way to promote anti-obesity by consuming energy as heat rather than storing it as triacylglycerols. Over the last decade, growing evidence has identified the gut microbiota as a potential factor in the pathophysiology of obesity. Calebin A is a non-curcuminoid novel compound derived from the rhizome of medicinal turmeric with putative anti-obesity effects. However, its ability on promoting thermogenesis and modulating gut microbiota remain unclear. Experimental procedure: C57BL/6J mice were fed either normal diet or high-fat diet (HFD) supplement with calebin A (0.1 and 0.5%) diet for 12 weeks. The composition of the gut microbiota was assessed by analyzing 16S rRNA gene sequences. Results and conclusion: Mice treated with calebin A shows a remarkable alteration in microbiota composition compared with that of normal diet-fed or HFD-fed mice and is characterized by an enrichment of Akkermansia, Butyricicoccus, Ruminiclostridium_9, and unidentified_Ruminococcaceae. We also explored that calebin A reduce the weight and blood sugar of mice that are induced by HFD, and show a dose-dependent reaction. Moreover, calebin A decreases the weight of white, beige, and brown adipose tissue, and also restores liver weight. In cold exposure experiments, calebin A can better maintain rectal temperature through thermogenesis. In summary, calebin A has a good thermogenesis function and is effective in anti-obesity. It can be used as a novel gut microbiota modulator to prevent HFD-induced obesity. ? 2022 Center for Food and Biomolecules, National Taiwan University |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122628594&doi=10.1016%2fj.jtcme.2022.01.001&partnerID=40&md5=ae8ba0f06ad5c3f48b58a774d1d724b4 https://scholars.lib.ntu.edu.tw/handle/123456789/606149 |
ISSN: | 22254110 | DOI: | 10.1016/j.jtcme.2022.01.001 |
顯示於: | 食品科技研究所 |
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