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  1. NTU Scholars
  2. 生物資源暨農學院
  3. 生物科技研究所
Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/606193
Title: More than causing (epi)genomic instability: emerging physiological implications of transposable element modulation
Authors: Hsu P.-S
Yu S.-H
Tsai Y.-T
Chang J.-Y
Tsai L.-K
Ye C.-H
Song N.-Y
Yau L.-C
Lin S.-P.
SHAU-PING LIN 
Keywords: Differentiation;Enhancers;Epigenetics;Evolution;Functional RNAs;Transposable elements (TEs);long untranslated RNA;microRNA;RNA;cell function;chromatin;chromosome inactivation;cis gene;DNA methylation;DNA sequence;epigenetics;gene;gene control;gene expression;gene function;genetic association;genetic transcription;genomic instability;histone modification;host cell;human;nonhuman;oocyte;physiological process;Review;trans gene;transposon;X chromosome;zygote
Issue Date: 2021
Journal Volume: 28
Journal Issue: 1
Source: Journal of Biomedical Science
Abstract: 
Transposable elements (TEs) initially attracted attention because they comprise a major portion of the genomic sequences in plants and animals. TEs may jump around the genome and disrupt both coding genes as well as regulatory sequences to cause disease. Host cells have therefore evolved various epigenetic and functional RNA-mediated mechanisms to mitigate the disruption of genomic integrity by TEs. TE associated sequences therefore acquire the tendencies of attracting various epigenetic modifiers to induce epigenetic alterations that may spread to the neighboring genes. In addition to posting threats for (epi)genome integrity, emerging evidence suggested the physiological importance of endogenous TEs either as cis-acting control elements for controlling gene regulation or as TE-containing functional transcripts that modulate the transcriptome of the host cells. Recent advances in long-reads sequence analysis technologies, bioinformatics and genetic editing tools have enabled the profiling, precise annotation and functional characterization of TEs despite their challenging repetitive nature. The importance of specific TEs in preimplantation embryonic development, germ cell differentiation and meiosis, cell fate determination and in driving species specific differences in mammals will be discussed. ? 2021, The Author(s).
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112644698&doi=10.1186%2fs12929-021-00754-2&partnerID=40&md5=65751cfb743c29eb8a0de281886d4f4f
https://scholars.lib.ntu.edu.tw/handle/123456789/606193
ISSN: 10217770
DOI: 10.1186/s12929-021-00754-2
SDG/Keyword: [SDGs]SDG3
Appears in Collections:生物科技研究所

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臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

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