Polyol-assisted synthesis of spinel-type magnesium cobalt oxide nanochains for voltammetric determination of the antipsychotic drug thioridazine
Journal
Journal of Electroanalytical Chemistry
Journal Volume
898
Date Issued
2021
Author(s)
Koventhan C
Vinothkumar V
Chen S.-M
Veerakumar P
KING-CHUEN LIN
Abstract
In this work, a cost-effective, simple and scalable synthesis of nanostructured magnesium cobalt oxide (MgCo2O4) was presented by various methods. The structural morphology was evaluated by powder X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), Raman, Fourier-transform infrared spectrometry (FTIR), and X-ray photoelectron spectroscopy (XPS). Further, electrochemical measurements by electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV), and differential pulse voltammetry (DPV) revealed that the MgCo2O4-modified electrode showed good sensitivity (0.895 ?A ?M?1 cm?2), a wide linear range (0.5–1415.8 μM) and a relatively low detection limit (0.047 μM) towards the electrochemical determination of thioridazine (TZ, antipsychotic drug). Loading catalyst, pH, scan rate, and peak potential of TZ were optimized. The proposed sensor features excellent anti-interference ability, good cyclic stability, high reproducibility, and repeatability. The system has also been successfully applied for the detection of TZ in blood serum samples. ? 2021 Elsevier B.V.
Subjects
Antipsychotic drug
Electrochemical sensor
MgCo2O4
Nanoparticles
Polyol method
Alcohols
Chemical detection
Cost effectiveness
Cyclic voltammetry
Drug delivery
Electrochemical impedance spectroscopy
Electrochemical sensors
Field emission microscopes
Fourier transform infrared spectroscopy
Magnesium compounds
Scanning electron microscopy
X ray photoelectron spectroscopy
Cobalt oxides
Cost effective
Effective synthesis
Electrochemicals
Nanochains
Polyol methods
Spinel-type
Thioridazine
Voltammetric determination
Cobalt compounds
SDGs
Type
journal article