MitoTox: a comprehensive mitochondrial toxicity database
Journal
BMC Bioinformatics
Journal Volume
22
Date Issued
2021
Author(s)
Abstract
Background: Mitochondria play essential roles in regulating cellular functions. Some drug treatments and molecular interventions have been reported to have off-target effects damaging mitochondria and causing severe side effects. The development of a database for the management of mitochondrial toxicity-related molecules and their targets is important for further analyses. Results: To correlate chemical, biological and mechanistic information on clinically relevant mitochondria-related toxicity, a comprehensive mitochondrial toxicity database (MitoTox) was developed. MitoTox is an electronic repository that integrates comprehensive information about mitochondria-related toxins and their targets. Information and data related to mitochondrial toxicity originate from various sources, including scientific journals and other electronic databases. These resources were manually verified and extracted into MitoTox. The database currently contains over 1400 small-molecule compounds, 870 mitochondrial targets, and more than 4100 mitochondrial?toxin-target associations. Each MitoTox data record contains over 30 fields, including biochemical properties, therapeutic classification, target proteins, toxicological data, mechanistic information, clinical side effects, and references. Conclusions: MitoTox provides a fully searchable database with links to references and other databases. Potential applications of MitoTox include toxicity classification, prediction, reference and education. MitoTox is available online at http://www.mitotox.org. ? 2021, The Author(s).
Subjects
Database
Mitochondria
Mitochondrial toxicity
Toxin-target association
Database systems
Molecules
Toxicity
Biochemical properties
Cellular function
Comprehensive information
Electronic database
Electronic repositories
Scientific journals
Searchable database
Small molecules
Classification (of information)
protein
adverse drug reaction
factual database
human
mitochondrion
Databases, Factual
Drug-Related Side Effects and Adverse Reactions
Humans
Proteins
SDGs
Type
journal article