https://scholars.lib.ntu.edu.tw/handle/123456789/607084
標題: | Ultrasonic technologies in imaging and drug delivery | 作者: | Ho Y.-J Huang C.-C Fan C.-H Yeh C.-K. HAO-LI LIU |
關鍵字: | Blood–brain barrier opening;Diagnostic ultrasound imaging;Local drug release;Neuromodulation;Tumor therapy;Ultrasound contrast agent;bevacizumab;carboplatin;carmustine;contrast medium;dopamine 4 receptor;doxorubicin;florbetaben;irinotecan;paclitaxel;sulfur hexafluoride;temozolomide;trastuzumab;drug carrier;Alzheimer disease;artificial embolization;blood brain barrier;brain tumor;cancer therapy;diagnostic imaging;diagnostic value;disease assessment;drug delivery system;drug mixture;elastography;electron beam tomography;futurology;human;immunomodulation;loading drug dose;microbubble;neuromodulation;Parkinson disease;Review;synergistic effect;systematic review;theranostic nanomedicine;ultrasound;vaporization;chemistry;degenerative disease;drug therapy;echography;metabolism;Blood-Brain Barrier;Brain Neoplasms;Contrast Media;Drug Carriers;Humans;Microbubbles;Neurodegenerative Diseases;Ultrasonography | 公開日期: | 2021 | 卷: | 78 | 期: | 17-18 | 起(迄)頁: | 6119-6141 | 來源出版物: | Cellular and Molecular Life Sciences | 摘要: | Ultrasonic technologies show great promise for diagnostic imaging and drug delivery in theranostic applications. The development of functional and molecular ultrasound imaging is based on the technical breakthrough of high frame–rate ultrasound. The evolution of shear wave elastography, high-frequency ultrasound imaging, ultrasound contrast imaging, and super-resolution blood flow imaging are described in this review. Recently, the therapeutic potential of the interaction of ultrasound with microbubble cavitation or droplet vaporization has become recognized. Microbubbles and phase-change droplets not only provide effective contrast media, but also show great therapeutic potential. Interaction with ultrasound induces unique and distinguishable biophysical features in microbubbles and droplets that promote drug loading and delivery. In particular, this approach demonstrates potential for central nervous system applications. Here, we systemically review the technological developments of theranostic ultrasound including novel ultrasound imaging techniques, the synergetic use of ultrasound with microbubbles and droplets, and microbubble/droplet drug-loading strategies for anticancer applications and disease modulation. These advancements have transformed ultrasound from a purely diagnostic utility into a promising theranostic tool. ? 2021, The Author(s), under exclusive licence to Springer Nature Switzerland AG. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111077881&doi=10.1007%2fs00018-021-03904-9&partnerID=40&md5=b1c4500346643f74df8cc8899604cead https://scholars.lib.ntu.edu.tw/handle/123456789/607084 |
ISSN: | 1420682X | DOI: | 10.1007/s00018-021-03904-9 |
顯示於: | 電機工程學系 |
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