https://scholars.lib.ntu.edu.tw/handle/123456789/607282
標題: | Depth-dependent in vivo human skin backscattering spectra extraction from full-field optical coherence tomography | 作者: | Soundararajan R Hsu T.-W Qin Y Huang S.-L. SHENG-LUNG HUANG |
關鍵字: | Absorption spectroscopy;Backscattering;Diagnosis;Extraction;Fused silica;Hysteresis;Light sources;Optical data processing;Tissue;Back-scattered;Backscattering spectra;Depth dependents;Full-field optical coherence tomographies;Images processing;In-vivo;In-vivo human skin;Spectra's;Tomographic image processing;Tomographic images;Optical tomography;diagnostic imaging;human;optical coherence tomography;skin;Humans;Skin;Tomography, Optical Coherence | 公開日期: | 2022 | 卷: | 15 | 期: | 1 | 來源出版物: | Journal of Biophotonics | 摘要: | With homemade active crystalline fibers, we generated bright and broadband light sources for full-field optical coherence tomography, offering deep penetration into skin tissues with cellular resolution at a high frame rate. Extraction of backscattered spectra from the tissue has potential applications in biomedicine. The hysteresis nonlinearity of the piezoelectric transducer actuating the Mirau interferometer has been greatly reduced by a feedforward compensation approach. The linearized hysteresis response enables us to extract depth-dependent spectra accurately. To validate, the complex dispersion of a fused silica plate was characterized with 2% error. Further validation on an in vitro setting, the backscattered spectra from indocyanine green pigment and nonpigmented microspheres were obtained and verified. For in vivo skin measurement, the backscattered spectra show depth-dependent spectral shift and bandwidth variation due to the complex skin anatomy and pigment absorption. Such a high-speed spectra acquisition of in vivo deep tissue backscattering could lead to disease diagnosis in clinical settings. ? 2021 Wiley-VCH GmbH. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118171236&doi=10.1002%2fjbio.202100249&partnerID=40&md5=e08b9e713b60486141e1149dd73e6621 https://scholars.lib.ntu.edu.tw/handle/123456789/607282 |
ISSN: | 1864063X | DOI: | 10.1002/jbio.202100249 |
顯示於: | 電機工程學系 |
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