https://scholars.lib.ntu.edu.tw/handle/123456789/607283
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Wu P.-Y | en_US |
dc.contributor.author | Wu J.-H | en_US |
dc.contributor.author | YI-TING HSIEH | en_US |
dc.contributor.author | Chen L.C.-C | en_US |
dc.contributor.author | Cheng T | en_US |
dc.contributor.author | Wu P.-Y | en_US |
dc.contributor.author | Hsieh B.-J | en_US |
dc.contributor.author | Huang W.-L | en_US |
dc.contributor.author | SHENG-LUNG HUANG | en_US |
dc.contributor.author | WEI-LI CHEN | en_US |
dc.creator | Wu P.-Y;Wu J.-H;Hsieh Y.-T;Chen L.C.-C;Cheng T;Wu P.-Y;Hsieh B.-J;Huang W.-L;Huang S.-L;Chen W.-L. | - |
dc.date.accessioned | 2022-04-25T06:43:06Z | - |
dc.date.available | 2022-04-25T06:43:06Z | - |
dc.date.issued | 2021 | - |
dc.identifier.issn | 20452322 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115275779&doi=10.1038%2fs41598-021-97567-y&partnerID=40&md5=2fc7e8df707a00a4c1635bebb27e3f02 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/607283 | - |
dc.description.abstract | This study aimed to evaluate the reliability of in vivo confocal microscopic neuroanalysis by beginners using manual and automated modules. Images of sub-basal corneal nerve plexus (SCNP) from 108 images of 18 healthy participants were analyzed by 7 beginner observers using manual (CCMetrics, [CCM]) and automated (ACCMetrics, [ACCM]) module. SCNP parameters analyzed included corneal nerve fiber density (NFD), corneal nerve branch density (NBD), corneal nerve fiber length (NFL), and tortuosity coefficient (TC). The intra-observer repeatability, inter-observer reliability, inter-module agreement, and left–right eye symmetry level of SCNP parameters were examined. All observers showed good intra-observer repeatability using CCM (intraclass correlation coefficient [ICC] > 0.60 for all), except when measuring TC. Two observers demonstrated especially excellent repeatability in analyzing NFD, NBD, and NFL using manual mode, indicating the quality of interpretation may still be observer-dependent. Among all SCNP parameters, NFL had the best inter-observer reliability (Spearman’s rank-sum correlation coefficient [SpCC] and ICC > 0.85 for the 3 original observers) and left–right symmetry level (SpCC and ICC > 0.60). In the additional analysis of inter-observer reliability using results by all 7 observers, only NFL showed good inter-observer reliability (ICC = 0.79). Compared with CCM measurements, values of ACCM measurements were significantly lower, implying a poor inter-module agreement. Our result suggested that performance of quantitative corneal neuroanalysis by beginners maybe acceptable, with NFL being the most reliable parameter, and automated method cannot fully replace manual work. ? 2021, The Author(s). | - |
dc.relation.ispartof | Scientific Reports | - |
dc.subject | adult | - |
dc.subject | article | - |
dc.subject | controlled study | - |
dc.subject | correlation coefficient | - |
dc.subject | eye | - |
dc.subject | female | - |
dc.subject | human | - |
dc.subject | human experiment | - |
dc.subject | in vivo study | - |
dc.subject | interrater reliability | - |
dc.subject | major clinical study | - |
dc.subject | male | - |
dc.subject | manual labor | - |
dc.subject | nerve fiber | - |
dc.subject | nerve plexus | - |
dc.subject | quantitative analysis | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.title | Comparing the results of manual and automated quantitative corneal neuroanalysing modules for beginners | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1038/s41598-021-97567-y | - |
dc.identifier.pmid | 34521890 | - |
dc.identifier.scopus | 2-s2.0-85115275779 | - |
dc.relation.journalvolume | 11 | - |
dc.relation.journalissue | 1 | - |
item.fulltext | no fulltext | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Ophthalmology-NTUH | - |
crisitem.author.dept | Division of Retina | - |
crisitem.author.dept | Ophthalmology | - |
crisitem.author.dept | Photonics and Optoelectronics | - |
crisitem.author.dept | Electrical Engineering | - |
crisitem.author.dept | Center for Artificial Intelligence and Advanced Robotics | - |
crisitem.author.dept | Ophthalmology | - |
crisitem.author.dept | Ophthalmology-NTUH | - |
crisitem.author.dept | Division of Cornea | - |
crisitem.author.orcid | 0000-0003-2258-154X | - |
crisitem.author.orcid | 0000-0001-6244-1555 | - |
crisitem.author.orcid | 0000-0002-1538-2414 | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | Ophthalmology-NTUH | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Electrical Engineering and Computer Science | - |
crisitem.author.parentorg | College of Electrical Engineering and Computer Science | - |
crisitem.author.parentorg | Others: University-Level Research Centers | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | Ophthalmology-NTUH | - |
顯示於: | 電機工程學系 |
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