Programmed Death Ligand 2 Gene Polymorphisms Are Associated With Lung Adenocarcinoma Risk in Female Never-Smokers
Journal
Frontiers in oncology
Journal Volume
11
Date Issued
2021
Author(s)
Chien, Li-Hsin
Chang, Gee-Chen
Tsai, Ying-Huang
Su, Wu-Chou
Chen, Yuh-Min
Huang, Ming-Shyan
Lin, Hsien-Chih
Fang, Wen-Tsen
Hung, Hsiao-Han
Jiang, Shih-Sheng
Chen, Chih-Yi
Chang, I-Shou
Hsiung, Chao A
Chen, Chien-Jen
Abstract
Lung cancer in never-smokers is a distinct disease associated with a different genomic landscape, pathogenesis, risk factors, and immune checkpoint inhibitor responses compared to those observed in smokers. This study aimed to identify novel single nucleotide polymorphisms (SNPs) of programmed death-1 (encoded by PDCD1) and its ligands, programmed death ligand 1 (CD274) and 2 (PDCD1LG2), associated with lung cancer risk in never-smoking women.
Subjects
carcinogenesis; lung adenocarcinoma; programmed death ligand-2; pulmonary tuberculosis; single nucleotide polymorphism
SDGs
Publisher
FRONTIERS MEDIA SA
Type
journal article