https://scholars.lib.ntu.edu.tw/handle/123456789/608172
標題: | Bacteriophages and phage-delivered CRISPR-Cas system as antibacterial therapy | 作者: | Yeh, Ting-Kuang Jean, Shio-Shin Lee, Yu-Lin Lu, Min-Chi Ko, Wen-Chien Lin, Hsueh-Ju Liu, Po-Yu PO-REN HSUEH |
關鍵字: | Antimicrobial; Bacteriophage therapy; CRISPR-Cas; Phage-based vector | 公開日期: | 一月-2022 | 出版社: | ELSEVIER | 卷: | 59 | 期: | 1 | 來源出版物: | International journal of antimicrobial agents | 摘要: | Multidrug-resistant (MDR) bacterial infections in humans are increasing worldwide. The global spread of antimicrobial resistance poses a considerable threat to human health. Phage therapy is a promising approach to combat MDR bacteria. An increasing number of reports have been published on phage therapy and the successful application of antibacterials derived using this method. Additionally, the CRISPR-Cas system has been used to develop antimicrobials with bactericidal effects in vivo. The CRISPR-Cas system can be delivered into target bacteria in various ways, with phage-based vectors being reported as an effective method. In this review, we briefly summarise the results of randomised control trials on bacteriophage therapy. Moreover, we integrated mechanisms of the CRISPR-Cas system antimicrobials in a schematic diagram and consolidated the research on phage-delivered CRISPR-Cas system antimicrobials. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/608172 | ISSN: | 0924-8579 | DOI: | 10.1016/j.ijantimicag.2021.106475 |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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