The association between metabolically healthy obesity, cardiovascular disease, and all-cause mortality risk in asia: A systematic review and meta-analysis
Journal
International Journal of Environmental Research and Public Health
Journal Volume
17
Journal Issue
4
Date Issued
2020
Author(s)
Huang M.-Y.
Wang M.-Y.
Lin Y.-S.
Lin C.-J.
Lo K.
Chang I.-J.
Cheng T.-Y.
Tsai S.-Y.
Chen H.-H.
Lin C.-Y.
Liu S.J.
Yeh T.-L.
Abstract
We investigated the association among metabolically healthy obesity (MHO), cardiovascular disease (CVD)risk, and all-cause mortality in the Asian population. We searched databases from inception to 16 November, 2019 and pooled data using a random-effects model. Subgroup analysis was conducted according to the following comparison groups: MHNW (without overweight or underweight participants) and MHNO (non-obese, including overweight and underweight participants). Nineteen studies were included. The mean Newcastle–Ottawa Scale score was 7.8. Participants with MHO had a significantly higher CVD risk (odds ratio (OR) = 1.36, 95% confidence interval (CI) = 1.13–1.63) and significantly lower risk of all-cause mortality (OR = 0.88, 95% CI = 0.78–1.00) than the comparison group. Subgroup analyses revealed participants with MHO had a significantly higher CVD risk than MHNW participants (OR = 1.61; 95% CI = 1.24–2.08; I2 = 73%), but there was no significant difference compared with MHNO participants (OR, 1.04; 95% CI, 0.80–1.36; I2 = 68%). Participants with MHO had a significantly lower risk of all-cause mortality (OR = 0.83; 95% CI = 0.78–0.88; I2 = 9%) than MHNO participants, but a borderline significantly higher risk of all-cause mortality than MHNW participants (OR = 1.30; 95% CI = 0.99–1.72; I2 = 0%). The CVD risk and all-cause mortality of the MHO group changed depending on the control group. Thus, future studies should select control groups carefully.
SDGs
Publisher
MDPI AG
Type
journal article