https://scholars.lib.ntu.edu.tw/handle/123456789/608979
標題: | Fasting and postchallenge hyperglycemia and risk of cardiovascular disease in Chinese: The Chin-Shan Community Cardiovascular Cohort study | 作者: | KUO-LIONG CHIEN Hsu, Hsiu-Ching TA-CHEN SU MING-FONG CHEN Lee, Yuan-Teh Hu, Frank B. |
公開日期: | 2008 | 卷: | 156 | 期: | 5 | 起(迄)頁: | 996-1002 | 來源出版物: | American Heart Journal | 摘要: | Background: Whether fasting glucose is superior to postchallenge glucose or insulin level for prediction of cardiovascular disease (CVD) remains controversial. The aim of our study was to compare fasting, postchallenge glucose and other markers as predictors of CVD in a community-based prospective cohort study among 2,165 adult participants. Methods: A standard 75-g oral glucose tolerance test was performed, with measurements of fasting and 2-hour postchallenge plasma glucose and insulin levels. We defined the CVD outcome as incident coronary heart disease and stroke. Cox regression model was used to estimate the relative risk (RR) for CVD. Results: A total of 166 individuals developed major CVD events during 10.5 years of follow-up. Both fasting and postchallenge glucose were significantly associated with CVD risk (adjusted RR in the highest quartile vs the lowest quartile 1.74, 95% confidence interval [CI] 1.06-2.86 for fasting glucose; RR in highest quartile 2.05, 95% CI 1.23-3.42 for postchallenge glucose). Postchallenge and fasting glucose had similar areas of receiver operative characteristics curves (0.65, 95% CI 0.58-0.72 for postchallenge glucose; 0.65, 95% CI 0.58-0.72 for fasting glucose). In mutually adjusted models, fasting and postchallenge glucose remained significant risk factors for CVD, whereas insulin resistance variables became nonsigificant. Conclusions: These findings show that fasting and postchallenge glucose concentrations are independent predictors of CVD risk among ethnic Chinese in Taiwan. © 2008 Mosby, Inc. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-54349109531&doi=10.1016%2fj.ahj.2008.06.019&partnerID=40&md5=5e7f1e95128d4474ec0a1204ad2f400c https://scholars.lib.ntu.edu.tw/handle/123456789/608979 |
ISSN: | 0002-8703 | DOI: | 10.1016/j.ahj.2008.06.019 |
顯示於: | 流行病學與預防醫學研究所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。