Relation of systemic arterial pulse pressure to coronary atherosclerosis in patients with mitral stenosis
Journal
American Journal of Cardiology
Journal Volume
80
Journal Issue
8
Pages
1035-1039
Date Issued
1997
Author(s)
Lee, Tsung-Ming
Lin, Yueh-Juh
Su, Sheng-Fang
Liau, Chiau-Suong
Lee, Yuan-Teh
Abstract
The relation of a wide systemic arterial pulse pressure to coronary atherosclerosis has not been fully defined. One hundred fifty-nine patients > 40 years old with symptomatic mitral stenosis (MS) who received routine coronary angiography were classified into 2 groups according to the presence of > or = 50% diameter narrowing of > or = 1 coronary artery (n = 48) or no significant disease (n = 111). Pulse pressure was determined both by noninvasive sphygmomanometer and invasive catheterization methods. There were no significant differences in risk factors of coronary artery disease (CAD) or the severity of MS between the 2 groups. From multivariate logistic regression analysis, independent predictors of development of CAD in MS were age (standardized coefficient beta = 1.3437, p = 0.0025), gender (beta = 0.0107, p = 0.0105), mean blood pressure (beta = 1.1839, p = 0.0105), and pulse pressure (beta = 1.3157, p = 0.0008). A wide pulse pressure (> or = 60 mm Hg) correlated with the presence of angiographically significant CAD with a sensitivity and specificity of 88% and 77%. The negative predictive value was 93%. Pulse pressure assessed by sphygmomanometry provided important clinical information. A wide pulse pressure in patients with MS was associated with a high incidence of CAD.
SDGs
Type
journal article
File(s)![Thumbnail Image]()
Loading...
Name
03.pdf
Size
560.13 KB
Format
Adobe PDF
Checksum
(MD5):a500f35288c66ed5300f25fca149bae7