https://scholars.lib.ntu.edu.tw/handle/123456789/609447
標題: | Selective Activation of Endoplasmic Reticulum Stress by Reactive-Oxygen-Species-Mediated Ochratoxin A-Induced Apoptosis in Tubular Epithelial Cells | 作者: | Khoi, Chong-Sun Lin, Yu-Wen Chen, Jia-Huang Liu, Biing-Hui Lin, Tzu-Yu KUAN-YU HUNG CHIH-KANG CHIANG |
關鍵字: | ER stress; HK-2 cell; apoptosis; ochratoxin A; reactive oxygen species | 公開日期: | 11-十月-2021 | 出版社: | MDPI | 卷: | 22 | 期: | 20 | 來源出版物: | International journal of molecular sciences | 摘要: | Ochratoxin A (OTA), one of the major food-borne mycotoxins, impacts the health of humans and livestock by contaminating food and feed. However, the underlying mechanism of OTA nephrotoxicity remains unknown. This study demonstrated that OTA induced apoptosis through selective endoplasmic reticulum (ER) stress activation in human renal proximal tubular cells (HK-2). OTA increased ER-stress-related JNK and precursor caspase-4 cleavage apoptotic pathways. Further study revealed that OTA increased reactive oxygen species (ROS) levels, and N-acetyl cysteine (NAC) could reduce OTA-induced JNK-related apoptosis and ROS levels in HK-2 cells. Our results demonstrate that OTA induced ER stress-related apoptosis through an ROS-mediated pathway. This study provides new evidence to clarify the mechanism of OTA-induced nephrotoxicity. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/609447 | ISSN: | 16616596 | DOI: | 10.3390/ijms222010951 |
顯示於: | 醫學系 |
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