https://scholars.lib.ntu.edu.tw/handle/123456789/610400
標題: | Pilot imaging study of o-BMVC foci for discrimination of indeterminate cytology in diagnosing fine-needle aspiration of thyroid nodules | 作者: | Tseng, Ting-Yuan SHYANG-RONG SHIH CHENG-PING WANG Lin, Shang-Jyun I-SHIOW JAN Wang, Chiung-Lin Liu, Shin-Ya Chang, Cheng-Chung PEI-JEN LOU Chang, Ta-Chau |
關鍵字: | G-QUADRUPLEX STRUCTURES; SMALL-MOLECULE; DNA; VISUALIZATION; MANAGEMENT | 公開日期: | 2021 | 出版社: | NATURE PORTFOLIO | 卷: | 11 | 期: | 1 | 來源出版物: | Scientific reports | 摘要: | Fluorescence lifetime imaging microscopy of a fluorescence probe, 3,6-bis(1-methyl-2-vinylpyridinium) carbazole diiodide (o-BMVC), provides an objective method for preoperative diagnosis of fine-needle aspiration (FNA) of thyroid nodules. The key of this o-BMVC test of FNA smears is the measurement of the digital number of o-BMVC foci in the nucleus. Thus, there are three categories classified in the o-BMVC test, which are nondiagnostic for unsatisfactory samples, benign for less numbers of o-BMVC foci, and malignant for more numbers of o-BMVC foci. The discrimination of indeterminate (including atypia, follicular neoplasm, suspicious) cytology into benign or malignant cases can reduce diagnostic uncertainty and benefit clinical decision making. This pilot study strongly suggests that the o-BMVC test is an invaluable method for diagnosing FNA samples. Particularly, the combination of FNA cytology and the o-BMVC test holds great promise to improve the efficacy of diagnosis and reduce the healthcare costs. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/610400 | ISSN: | 2045-2322 | DOI: | 10.1038/s41598-021-02887-8 |
顯示於: | 醫學院附設醫院 (臺大醫院) |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。