https://scholars.lib.ntu.edu.tw/handle/123456789/610400
Title: | Pilot imaging study of o-BMVC foci for discrimination of indeterminate cytology in diagnosing fine-needle aspiration of thyroid nodules | Authors: | Tseng, Ting-Yuan SHYANG-RONG SHIH CHENG-PING WANG Lin, Shang-Jyun I-SHIOW JAN Wang, Chiung-Lin Liu, Shin-Ya Chang, Cheng-Chung PEI-JEN LOU Chang, Ta-Chau |
Keywords: | G-QUADRUPLEX STRUCTURES; SMALL-MOLECULE; DNA; VISUALIZATION; MANAGEMENT | Issue Date: | 2021 | Publisher: | NATURE PORTFOLIO | Journal Volume: | 11 | Journal Issue: | 1 | Source: | Scientific reports | Abstract: | Fluorescence lifetime imaging microscopy of a fluorescence probe, 3,6-bis(1-methyl-2-vinylpyridinium) carbazole diiodide (o-BMVC), provides an objective method for preoperative diagnosis of fine-needle aspiration (FNA) of thyroid nodules. The key of this o-BMVC test of FNA smears is the measurement of the digital number of o-BMVC foci in the nucleus. Thus, there are three categories classified in the o-BMVC test, which are nondiagnostic for unsatisfactory samples, benign for less numbers of o-BMVC foci, and malignant for more numbers of o-BMVC foci. The discrimination of indeterminate (including atypia, follicular neoplasm, suspicious) cytology into benign or malignant cases can reduce diagnostic uncertainty and benefit clinical decision making. This pilot study strongly suggests that the o-BMVC test is an invaluable method for diagnosing FNA samples. Particularly, the combination of FNA cytology and the o-BMVC test holds great promise to improve the efficacy of diagnosis and reduce the healthcare costs. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/610400 | ISSN: | 2045-2322 | DOI: | 10.1038/s41598-021-02887-8 |
Appears in Collections: | 醫學院附設醫院 (臺大醫院) |
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