https://scholars.lib.ntu.edu.tw/handle/123456789/610545
標題: | BLMP-1 promotes developmental cell death in C. elegans by timely repression of ced-9 transcription | 作者: | Jiang, Hang-Shiang Ghose, Piya Han, Hsiao-Fen Wu, Yun-Zhe Tsai, Ya-Yin Lin, Huang-Chin Tseng, Wei-Chin JUI-CHING WU Shaham, Shai Wu, Yi-Chun |
關鍵字: | Caenorhabditis elegans; BLMP-1/Blimp1; CED-9/BCL2; Developmental timing; Programmed cell death | 公開日期: | 2021 | 出版社: | COMPANY BIOLOGISTS LTD NLM (Medline) |
卷: | 148 | 期: | 20 | 來源出版物: | Development (Cambridge, England) | 摘要: | Programmed cell death (PCD) is a common cell fate in metazoan development. PCD effectors are extensively studied, but how they are temporally regulated is less understood. Here, we report a mechanism controlling tail-spike cell death onset during Caenorhabditis elegans development. We show that the zinc-finger transcription factor BLMP-1, which controls larval development timing, also regulates embryonic tail-spike cell death initiation. BLMP-1 functions upstream of CED-9 and in parallel to DRE-1, another CED-9 and tail-spike cell death regulator. BLMP-1 expression is detected in the tail-spike cell shortly after the cell is born, and blmp-1 mutations promote ced-9-dependent tail-spike cell survival. BLMP-1 binds ced-9 gene regulatory sequences, and inhibits ced-9 transcription just before cell-death onset. BLMP-1 and DRE-1 function together to regulate developmental timing, and their mammalian homologs regulate B-lymphocyte fate. Our results, therefore, identify roles for developmental timing genes in cell-death initiation, and suggest conservation of these functions. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/610545 | ISSN: | 0950-1991 14779129 |
DOI: | 10.1242/dev.193995 |
顯示於: | 醫學檢驗暨生物技術學系 |
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