https://scholars.lib.ntu.edu.tw/handle/123456789/610550
標題: | Host Genetic Associations with Salivary Microbiome in Oral Cancer | 作者: | Yang, S F Lin, C W Chuang, C Y Lee, Y C Chung, W H HSIN-CHIH LAI Chang, L C Su, S C |
關鍵字: | dysbiosis; genotype; microbiome genome-wide association study; oral microbiota; oral squamous cell carcinoma; quantitative trait loci | 公開日期: | 五月-2022 | 出版社: | SAGE PUBLICATIONS INC | 卷: | 101 | 期: | 5 | 起(迄)頁: | 590 | 來源出版物: | Journal of dental research | 摘要: | Despite the growing recognition of a host genetic effect on shaping gut microbiota composition, the genetic determinants of oral microbiota remain largely unexplored, especially in the context of oral diseases. Here, we performed a microbiome genome-wide association study in 2 independent cohorts of patients with oral squamous cell carcinoma (OSCC, n = 144 and 67) and an additional group of noncancer individuals (n = 104). Besides oral bacterial dysbiosis and signatures observed in OSCC, associations of 3 loci with the abundance of genus-level taxa and 4 loci with β diversity measures were detected (q < 0.05) at the discovery stage. The most significant hit (rs10906082 with the genus Lachnoanaerobaculum, P = 3.55 × 10-9 at discovery stage) was replicated in a second OSCC cohort. Moreover, the other 2 taxonomical associations, rs10973953 with the genus Kingella (P = 1.38 × 10-9) and rs4721629 with the genus Parvimonas (P = 3.53 × 10-8), were suggestive in the meta-analysis combining 2 OSCC cohorts. Further pathway analysis revealed that these loci were enriched for genes in regulation of oncogenic and angiogenic responses, implicating a genetic anchor to the oral microbiome in estimation of casual relationships with OSCC. Our findings delineate the role of host genotypes in influencing the structure of oral microbial communities. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/610550 | ISSN: | 0022-0345 | DOI: | 10.1177/00220345211051967 |
顯示於: | 醫學檢驗暨生物技術學系 |
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