https://scholars.lib.ntu.edu.tw/handle/123456789/611059
標題: | External light-dark cycle shapes gut microbiota through intrinsically photosensitive retinal ganglion cells | 作者: | Lee, Chi Chan Liang, Feng Lee, I. Chi Lu, Tsung Hao Shan, Yu Yau Jeng, Chih Fan Zou, Yan Fang HON-TSEN YU SHIH-KUO CHEN |
關鍵字: | dim light at night | gut microbiota | ipRGC | melanopsin | 公開日期: | 1-一月-2022 | 出版社: | John Wiley and Sons Inc | 卷: | 23 | 期: | 6 | 起(迄)頁: | Article number e52316 | 來源出版物: | EMBO Reports | 摘要: | Gut microbiota are involved in many physiological functions such as metabolism, brain development, and neurodegenerative diseases. Many microbes in the digestive tract do not maintain a constant level of their relative abundance but show daily oscillations under normal conditions. Recent evidence indicates that chronic jetlag, constant darkness, or deletion of the circadian core gene can alter the composition of gut microbiota and dampen the daily oscillation of gut microbes. However, the neuronal circuit responsible for modulating gut microbiota remained unclear. Using genetic mouse models and 16s rRNA metagenomic analysis, we find that light-dark cycle information transmitted by the intrinsically photosensitive retinal ganglion cells (ipRGCs) is essential for daily oscillations of gut microbes under temporal restricted high-fat diet conditions. Furthermore, aberrant light exposure such as dim light at night (dLAN) can alter the composition, relative abundance, and daily oscillations of gut microbiota. Together, our results indicate that external light-dark cycle information can modulate gut microbiota in the direction from the brain to the gut via the sensory system. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/611059 | ISSN: | 1469221X | DOI: | 10.15252/embr.202052316 |
顯示於: | 生命科學系 |
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