Mild Chronic Colitis Triggers Parkinsonism in LRRK2 Mutant Mice Through Activating TNF-α Pathway
Journal
Movement disorders : official journal of the Movement Disorder Society
Journal Volume
37
Journal Issue
4
Pages
745
Date Issued
2022-04
Author(s)
Lin, Han-Yi
Ho, En-Pong
Ke, Yi-Ci
Shiue, Chyng-Yann
Wu, Chi-Han
Liao, Peng-Hsiang
Hsu, Angela Yu-Huey
Chu, Li-An
Liu, Ya-Ding
Lin, Ya-Hui
Tai, Yi-Cheng
Abstract
Leucine-rich repeat kinase 2 (LRRK2) is a common risk gene for Parkinson's disease (PD) and inflammatory bowel disorders. However, the penetrance of the most prevalent LRRK2 mutation, G2019S, is <50%. Factors other than genetic mutations are needed in PD process.
Subjects
Parkinson's diseasegut inflammationinflammatory bowel diseasegut-brain axisleucine-rich repeat kinase 2tumor necrosis factor-alpha
Publisher
WILEY
Type
journal article