https://scholars.lib.ntu.edu.tw/handle/123456789/611146| Title: | Mild Chronic Colitis Triggers Parkinsonism in LRRK2 Mutant Mice Through Activating TNF-α Pathway | Authors: | Lin, Chin-Hsien Lin, Han-Yi Ho, En-Pong Ke, Yi-Ci Cheng, Mei-Fang Shiue, Chyng-Yann Wu, Chi-Han Liao, Peng-Hsiang Hsu, Angela Yu-Huey Chu, Li-An Liu, Ya-Ding Lin, Ya-Hui Tai, Yi-Cheng CHIA-TUNG SHUN Chiu, Han-Mo Wu, Ming-Shiang |
Keywords: | Parkinson's diseasegut inflammationinflammatory bowel diseasegut-brain axisleucine-rich repeat kinase 2tumor necrosis factor-alpha | Issue Date: | Apr-2022 | Publisher: | WILEY | Journal Volume: | 37 | Journal Issue: | 4 | Start page/Pages: | 745 | Source: | Movement disorders : official journal of the Movement Disorder Society | Abstract: | Leucine-rich repeat kinase 2 (LRRK2) is a common risk gene for Parkinson's disease (PD) and inflammatory bowel disorders. However, the penetrance of the most prevalent LRRK2 mutation, G2019S, is <50%. Factors other than genetic mutations are needed in PD process. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/611146 | ISSN: | 0885-3185 | DOI: | 10.1002/mds.28890 |
| Appears in Collections: | 法醫學科所 |
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